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Doctoral Thesis
DOI
https://doi.org/10.11606/T.42.2011.tde-20012012-090811
Document
Author
Full name
Luciana Lima
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2011
Supervisor
Committee
Teixeira, Marta Maria Geraldes (President)
Franken, Ana Maria Jansen
Morgante, Joao Stenghel
Mortara, Renato Arruda
Rosa, Joao Aristeu da
Title in Portuguese
Diversidade morfológica, biológica e genética, e relações filogenéticas de tripanossomas de morcegos do Brasil e Moçambique (África).
Keywords in Portuguese
Trypanosoma
Diversidade genética
Filogenia
Genótipos
Morcegos
Zoologia (classificação)
Abstract in Portuguese
Embora os morcegos sejam hospedeiros de tripanossomas de vários subgêneros, o conhecimento sobre a diversidade genética, variedade de hospedeiros, vetores, ciclos de vida, distribuição geográfica e relações filogenéticas desses tripanossomas é muito limitado. Neste estudo, caracterizamos tripanossomas de morcegos do Brasil e de Moçambique (África). A diversidade morfológica, biológica e genética e o relacionamento filogenético de espécies de Schizotrypanum revelaram os clados T. dionisii e T. c. marinkellei (restritos a morcegos) e T. cruzi. Nossos resultados permitiram descrever um novo genótipo de T. cruzi e uma nova espécie desse subgênero em morcegos africanos. Confirmamos, com análises filogenéticas, a presença de T. rangeli em morcegos e caracterizamos uma nova espécie, tradicionalmente classificada como Megatrypanum, mas filogeneticamente não posicionada neste subgênero. Novas análises, visando melhor resolver as filogenias e estimar tempos de divergências, são necessárias para inferir a hipótese mais provável para a história evolutiva desses tripanossomas.
Title in English
Morphological, biological and genetic diversity, and phylogenetic relationships of bat trypanosomes from Brazil and Mozambique (Africa).
Keywords in English
Trypanosoma
Bats
Genetic diversity
Genotypes
Phylogeny
Zoology (classification)
Abstract in English
Although bats are hosts of trypanosomes from several subgenera, our knowledge regarding their genetic diversity, host-range, vectors, life-cycles, geographical distribution and phylogenetic relationships is very limited. Here, we characterized bat trypanosomes from Brazil and Mozambique (Africa). Morphological, biological and genetic diversity, and phylogenetic relationships of Schizotrypanum species disclosed T. dionisii, T. c. marinkellei (bat restricted) and T. cruzi clades. Our findings also enabled the description of a new genotype of T. cruzi and a new species of this subgenus infecting African bats. We also reported T. rangeli in bats confirmed by phylogenetic analysis and characterized a new species of bat trypanosome traditionally classified as Megatrypanum, but not phylogenetically supported in this subgenus. Further analyses aiming better-resolved phylogenies and reliable molecular-clock model to estimate divergence times are required to infer the most likely hypothesis for the evolutionary history of bat trypanosomes.
 
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Publishing Date
2012-02-09
 
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