Leishmaniose em Assis Brasil com ênfase na fauna de flebotomíneos e agentes etiológicos circulantes na área de fronteira.

Teles, Carolina Bioni Garcia

doi:10.11606/T.42.2015.tde-27082015-152859

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DOI

https://doi.org/10.11606/T.42.2015.tde-27082015-152859

Document

Doctoral Thesis

Author

Teles, Carolina Bioni Garcia (Catálogo USP)

Full name

Carolina Bioni Garcia Teles

Institute/School/College

Instituto de Ciências Biomédicas

Knowledge Area

Biology of Host-Pathogen Interactions

Date of Defense

2015-04-09

Published

São Paulo, 2015

Supervisor

Camargo, Luís Marcelo Aranha (Catálogo USP)

Committee

Camargo, Luís Marcelo Aranha (President)
Bruno, Rafaela Vieira
Ribolla, Paulo Eduardo Martins
Rocha, Lincoln Suesdek
Winter, Carlos Eduardo

Title in Portuguese

Leishmaniose em Assis Brasil com ênfase na fauna de flebotomíneos e agentes etiológicos circulantes na área de fronteira.

Keywords in Portuguese

Epidemiologia
Estado do Acre
Fauna de flebotomíneos
Leishmaniose

Abstract in Portuguese

O objetivo desse trabalho foi: identificar as espécies de flebotomíneos, estimar a taxa de infecção dos flebotomíneos, identificar os agentes etiológicos envolvidos na transmissão da LTA no município de Assis Brasil, Acre. Foi realizada a PCR para a identificação de espécies de Leishmania em amostras de flebotomíneos e biópsias humanas. Um total de 6.850 exemplares foram capturados pertencentes a 66 espécies de flebotomíneos. As espécies mais abundantes foram Lu. auraensis, Lu. davisi, Lu. choti e Lu. shawi. Trinta e dois pools foram positivos para a presença de DNA de Leishmania com uma prevalência mínima de infecção de 1,85% para Lu. davisi e de 2,05% para Lu. auraensis. As espécies de Leishmania detectadas foram: Le. (Viannia) guyanensis e Le. (V.) braziliensis. Além dessas, outras duas espécies de Leishmania foram encontradas a partir das biópsias de lesões: Le. (V.) shawi e Le. (Le.) amazonenses. A doença foi mais prevalente no sexo masculino e residente na zona rural. Esse é o primeiro registro de Le. (V.) shawi e Le. (L.) amazonenses no Acre.

Title in English

Leishmaniasis in Assis Brasil, AC, with emphasis on sandfly fauna and etiological agentes current in the border region.

Keywords in English

Acre state
Epidemiology
Leishmaniasis
Phlebotomine fauna

Abstract in English

The objectives of this study were: to identify phlebotominae species, to estimate infection rates of phlebotomines, to identify the etiological agents involved in ATL transmission in the municipality of Assis Brasil, Acre. The PCR was used to identify Leishmania species in phlebotomine and human biopsy samples. A total of 6,850 sandflies. comprising 66 species were captured. The most abundant species were Lu. auraensis, Lu. davisi, Lu. choti e Lu. shawi. Thirty-two pools tested positive for the presence of Leishmania DNA, with a minimum infection rate of 1.85% in Lu. davisi and 2.05% in Lu. auraensis. The Leishmania species were identified as Le. (Viannia) guyanensis and Le. (V.) braziliensis. In addition to these, two other Leishmania species were identified from lesion biopsies: Le. (V.) shawi and Le. (Le.) amazonenses. The disease was most common among males (81.6%) e and persons living in rural areas (75.7%). This is the first record of Le. (V.) shawi and Le. (Le.) amazonenses in Acre.

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Publishing Date

2015-08-28

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