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Master's Dissertation
DOI
https://doi.org/10.11606/D.76.2008.tde-07042008-133927
Document
Author
Full name
Guilherme da Costa Pereira Innocentini
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Carlos, 2008
Supervisor
Committee
Hornos, José Eduardo Martinho (President)
Bosco, Francisco de Assis Ribas
Fontanari, José Fernando
Title in Portuguese
Modelamento estocástico para a expressão gênica
Keywords in Portuguese
Estocasticidade
Expressão gênica
Regulação transcricional
Ruído
Abstract in Portuguese
Nesta dissertação consideramos um o modelo para um gene como sendo um sistema de dois estados, tipo spin, e apresentamos um modelo estocástico para a expressão gênica. As soluções estacionárias e, também, as dependentes do tempo, para o processo de transcrição, são obtidas e as distribuições de probabilidade, que descrevem o estado funcional do gene, são calculadas analiticamente. O valor médio e o ruído transcricional na população de mRNA são analisados. O efeito do ruído transcricional na síntese proteica é contemplado acoplando-se os processo de transcrição e tradução.
Title in English
Modeling stochastic gene expression
Keywords in English
Gene expression
Noise
Stochasticiy
Transcriptional regulation
Abstract in English
In this dissertation we present a two state stochastic model, spin-like, for gene expression. The steady-state solutions and also the time-dependente solutions for the transcription are probed and the probability distribution functions, which describe the functional state of the gene, are exactly calculated. The mean value and the transcriptional noise in the mRNA population are analyzed. The effects of the transcriptional noise in the protein synthesis are contemplated by coupling the transcription and the translation.
 
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Publishing Date
2008-04-09
 
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