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Master's Dissertation
DOI
10.11606/D.10.2014.tde-06012015-092943
Document
Author
Full name
Sandra Cássia Braga dos Santos
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2014
Supervisor
Committee
Cortopassi, Silvia Renata Gaido (President)
Futema, Fábio
Oliveira, Clair Motos de
Title in Portuguese
Efeito da raquianestesia com bupivacaína associada ou não à clonidina em gatas submetidas a ovariosalpingohisterectomia
Keywords in Portuguese
Bupivacaína isobárica
Clonidina
Gatos
Raquianestesia
Abstract in Portuguese
O presente estudo comparou os efeitos da raquianestesia com o anestésico local bupivacaína isobárica a 0,5% isolado ou associado ao agonista alfa adrenérgico clonidina em gatas anestesiadas com propofol e isofluorano para realização de ovariosalpingohisterectomia. Trinta gatas foram pré-tratadas com meperidina; decorridos 15 minutos, a indução da anestesia foi realizada com propofol, seguido de isofluorano para manutenção anestésica. As gatas foram distribuídas em três grupos, onde receberam, na raquianestesia: solução fisiológica (GSF); bupivacaína isobárica (GB), ou bupivacaína isobárica e clonidina (GBC). Todos os animais foram submetidos a ovariosalpingohisterectomia. As frequências cardíaca e respiratória, pressão arterial e temperatura retal foram mensuradas durante todos os momentos de avaliação. Durante a anestesia, foram incluídas as análises da fração expirada de dióxido de carbono, fração expirada de isofluorano e saturação da oxihemoglobina periférica. A hemogasometria foi realizada previamente a raquianestesia a ao término do procedimento cirúrgico. O grau de sedação, foi analisado no período de recuperação com auxílio de escore A raquianestesia com bupivacaína e clonidina não promoveu alterações na frequência e ritmo cardíaco, pressão arterial nem depressão respiratória tendo em vista que os valores de frequência respiratória e fração expirada de dóxido de carbono permaneceram dentro dos valores fisiológicos. O emprego de bupivacaína isolada e em associação à clonidina promoveu redução da concentração expirada de isofluorano (respectivamente 63,5% e 70) quando comparados ao grupo controle. O uso de clonidina determinou sedação no período de recuperação. O uso da raquianestesia com bupivacaína isobárica a 0,5% isolada ou em associação à clonidina demonstrou boa estabilidade hemodinâmica e significativa diminuição no requerimento de anestésico geral; a clonidina potencializou o efeito da bupivacaína isobárica no momento cirúrgico e apresentou grau satisfatório de sedação no período pós operatório
Title in English
Bupivacaine spinal anestesia effect with and without clonidine in female cats undergoing ovariohysterectomy
Keywords in English
Cats
Clonidine
Isobaric bupivacaine
Spinal anesthesia
Abstract in English
This study compares effects of spinal anesthesia with isobaric bupivacaine at 0,5% either isolated or associated to clonidine administered to female cats undergoing ovariohysterectomy under the effect of propofol and isoflurane. Meperidine was administered to thirty female cats whose anesthetic induction was performed 15 minutes later with the help of propofol followed by isoflurane for maintenance of anesthesia. The female cats were split into three different groups which received one of the following substances each for spinal anesthesia: physiological saline solution (GSF); isobaric bupivacaine (GB); isobaric bupivacaine and clonidine (GBC). All thirty animals underwent ovariohysterectomy. Heart and respiratory rate, blood pressure and rectal temperature were measured throughout the procedures. Under anesthesia, the fraction of expired carbon dioxide, the fraction of expired isoflurane and the saturation of oxihemoglobin were analyzed. Arterial blood gasometry was performed before spinal anesthesia and after surgical procedures. The level of sedation was analyzed during recovery with the help of scores from Selmi et al. (2004) Spinal anesthesia associated to bupivacaine and clonidine did not alter the heart rate, blood pressure or respiratory depression once the respiratory rate numbers and the fraction of expired carbon dioxide numbers ranged within the normal physiological values. The use of bupivacaine, either isolated or associated to clonidine, led to the reduction of the concentration of expired isoflurane (63,5% and 70% respectively) when compared to the control group. The use of clonidine led to sedation during recovery. The use of spinal anesthesia combined with isobaric bupivacaine at 0,5%, isolated or associated to clonidine, demonstrated good hemodynamic stability and a significant decrease in the need of general anesthesia; clonidine optimized the effect of isobaric bupivacaine throughout surgical procedures and also showed a satisfactory level of sedation during the postoperative period
 
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Publishing Date
2015-03-26
 
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