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Master's Dissertation
DOI
10.11606/D.11.2018.tde-25072018-181323
Document
Author
Full name
Rodrigo Rampazo Amadeu
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Piracicaba, 2018
Supervisor
Committee
Garcia, Antonio Augusto Franco (President)
Carneiro, Monalisa Sampaio
Colombo, Carlos Augusto
Oliveira, Giancarlo Conde Xavier
Title in English
Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
Keywords in English
Autotetraploids
Molecular marker
Molecular relationship
Polyploid
SNP
Abstract in English
Crops, such as sugarcane, potato, and several forages and berries, are autopolyploids. In plant breeding studies, a key subject is the pairwise relatedness between cultivars. This information can be incorporated in GWAS (genome-wide association) and GS (genomic selection) studies allowing powerful genetic analysis. Despite the autopolyploid importance in agriculture, they lack genetic studies considering ploidy level, and, therefore, polyssomic inheritance. Our objective in this work is: i) to investigate, through simulations, different molecular pairwise relatedness estimators; ii) to recommend which one is the best to be used in different scenarios regarding characteristic as number of loci, number of alleles, ploidy level, double-reduction, and inbreeding level. Our recommendations may guide autopolyploid breeding programs will be able to choose the best strategies and estimators based their reality.
Title in Portuguese
Parentesco molecular em autopoliploides: um estudo de simulação considerando lingação e muitos loci
Keywords in Portuguese
Autotetraploides
Marcador molecular
Parentesco molecular
Poliploides
SNP
Abstract in Portuguese
Culturas agrícolas como cana-de-açúcar, batata, batata doce, diferentes forrageiras e frutas são autopoliploides. Em melhoramento de plantas, o conhecimento do parentesco entre cultivares é crítico. Essa informação pode ser incorporada em estudos de GWAS (genome-wide association studies) e GS (genomic selection) permitindo uma análise genética e predição de QTLs e valores genéticos de maior poder estatístico. No entanto, faltam estudos genéticos que considerem parentesco em um cenário autopoliploide. Nossos objetivos neste trabalho são: i) investigar, através de simulações, diferentes estimadores de parentesco entre indivíduos; ii) recomendar o melhor estimador basedo em cenários específicos considerando diferentes número de loci, número de alelos, ploidia, nível de dupla-redução e endogamia. Nossas recomendações poderão orientar estratégias de programas de melhoramento genético de espécies autopoliploides para escolha de estimadores baseados em seu cenário específico.
 
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Release Date
2020-07-26
Publishing Date
2018-08-02
 
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