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Doctoral Thesis
DOI
https://doi.org/10.11606/T.11.2013.tde-25042013-171011
Document
Author
Full name
Ricardo Basso Zanon
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Piracicaba, 2013
Supervisor
Committee
Cyrino, Jose Eurico Possebon (President)
Menten, José Fernando Machado
Sado, Ricardo Yuji
Sartori Filho, Roberto
Urbinati, Elisabeth Criscuolo
Title in Portuguese
Perfil farmacocinético do levamisol e eficácia do uso de imunoestimulantes dietéticos em juvenis de surubim Pseudoplatystoma sp
Keywords in Portuguese
Aditivos alimentares
Alimentação animal
Dietética
Moduladores imunológicos
Peixes de água doce
Vitamina E
Abstract in Portuguese
Tendo em vista o notável crescimento da aquicultura mundial e principalmente a brasileira, torna-se cada vez mais importante o desenvolvimento de tecnologias que favoreçam esta prática. No entanto, a intensificação da piscicultura faz aumentar as chances de ocorrência de epizootias nos sistemas de produção como resultado do maior estresse imposto aos animais (lotação, manejo, transporte etc). Este estudo determinou a eficácia na utilização de imunoestimulantes dietéticos (levamisol e vitamina E) e a farmacocinética do imunoestimulante levamisol em juvenis de surubim Pseudoplatystoma sp. O levamisol dietético não afetou as variáveis de desempenho, mas influenciou positivamente o sistema imunológico inespecífico do cachara, afetando a atividade da lisozima sérica, sendo o melhor resultado observado para a concentração de levamisol de 247 mg kg-1 de ração. No estudo com vitamina E, não foram registrados efeitos sobre as variáveis de desempenho; ainda, na dose dietética 166 mg kg-1 o acetato de DL-?-tocoferol promoveu aumento das globulinas séricas. O estudo farmacocinético revelou-se que o levamisol é eliminado do sangue do cachara em 12 horas, sendo a meia-vida de distribuição (t1/2?) de 0,10 horas, e para o intervalo de eliminação meia-vida (t1/2?) de 1,86 horas.
Title in English
Pharmacokinetic study and efficiency of dietary immunostimulants in juvenile of Pseudoplatystoma sp.
Keywords in English
Animal nutrition
Dietetics
Feed additives
Fresh water fish
Immunological modulators
Vitamin E
Abstract in English
Continuous stress negatively influences the immune system of farmed fish, increasing diseases susceptibility. In such a context, preventive measures, such as the administration of immunostimulants, are better suited for diseases control than using drugs and chemicals as remedies. This study aimed to evaluate the effects of dietary immunostimulants (levamisole and vitamin E) as well as the pharmacokinetic study of levamisole in juvenile of Pseudoplatystoma sp. Dietary levamisole did not affect growth parameters. However, increased lysozyme activity and lysozyme concentration, the best effects were recorded for fish fed 247 mg levamisole per kg of feed. In the vitamin E assay, no differences in growth parameters were recorded. However, vitamin E levels positively influenced the innate immune system increasing serum globulins at dose of 166 mg kg-1 of DL-?-tocoferol acetate. Also, at pharmacokinetic study levamisole is shown to be completely eliminated from fish blood on a 12-h period, being the distribution half-life (t1/2?) of 0.10 hours, whilst for the elimination interval the half-life (t1/2?) was 1.86 hours.
 
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Publishing Date
2013-05-07
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • ZANON, R. B., et al. Pharmacokinetic of levamisole in speckled surubim Pseudoplatystoma corruscans [doi:10.1111/jvp.12002]. Journal of Veterinary Pharmacology and Therapeutics [online], 2013, vol. 36, p. 298-301.
  • ZANON, R. B., et al. Perfil farmacocinético do levamisol em pintado (Pseudoplatystoma corruscans). In Aqua Ciência 2010, Recife, PE, 2010. Anais do Aqua Ciência 2010 - Resumos.Recife, PE : Universidade Federal Rural de Pernambuco e Sociedade Brasileira de Aquicultura e Biologia Aquática, 2010. Resumo.
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