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Master's Dissertation
DOI
10.11606/D.11.2013.tde-21022013-104731
Document
Author
Full name
Maressa Caldeira Morzelle
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Piracicaba, 2013
Supervisor
Committee
Salgado, Jocelem Mastrodi (President)
Brazaca, Solange Guidolin Canniatti
Trindade, Carmen Silvia Favaro
Title in Portuguese
Resíduos de romã (Punica granatum) na prevenção da doença de Alzheimer
Keywords in Portuguese
Alimentos funcionais
Anticolinérgicos
Antioxidantes
Doença de Alzheimer
Doenças neurodegenerativas
Microencapsulação
Romã
Abstract in Portuguese
Os inibidores da enzima acetilcolinesterase constituem o principal tratamento da doença de Alzheimer e fontes de substâncias naturais com potencial anticolinesterásico vêm sendo amplamente estudadas. Dentre os frutos com benefícios para a saúde, a romã é evidenciada como excelente fonte de compostos antioxidantes, sendo que maior parte dos compostos se concentram em sua casca. Com base nisso, o objetivo desta pesquisa foi buscar novas substâncias naturais com potencial anticolinesterásico, através da avaliação de extratos de casca de romã. Quatro extratos com diferentes concentrações de etanol foram analisados quanto à atividade antioxidante, quantidade de compostos fenólicos, taninos e atividade anticolinesterásica. Do presente estudo foi constatado que a casca da romã apresentou elevada capacidade antioxidante, independente da concentração do solvente de extração empregado. O extrato formulado com 80% de etanol se destacou perante os demais pelo seu poder de inibição da acetilcolinesterase. Houve correlação negativa entre a atividade anticolinesterásica e a atividade antioxidante dos extratos. A atomização do extrato não acarretou mudanças em sua atividade anticolinesterásica e nem na sua capacidade antioxidante. Da mesma forma, a adição das micropartículas a um suco elaborado a partir de um preparado em pó não modificou suas características sensoriais. Diante do exposto, a elaboração de micropartículas de extrato de casca de romã constitui alternativa viável para a incorporação em diversos produtos, com a finalidade de prevenir ou reduzir risco da doença de Alzheimer.
Title in English
Waste of pomegranate (Punica granatum) in the prevention of Alzheimer's disease
Keywords in English
Anticholinesterase
Antioxidant activity
Functional foods
Microencapsulation
Neurodegenerative diseases
Abstract in English
The acetylcholinesterase inhibitors are the primary treatment of Alzheimer's disease and sources of natural substances with potential anticholinesterase have been widely studied. Among the fruits with health benefits, the pomegranate is evidenced as an excellent source of antioxidant compounds, and most compounds are concentrated in its peel. Based on this, the objective of this research was to find new substances with potential anticholinesterase, through the evaluation of pomegranate peel extracts. Four extracts with different concentrations of ethanol were analyzed for their antioxidant activity, amount of phenolic compounds, tannins and anticholinesterase activity. From this study it was found that pomegranate peel showed high antioxidant capacity, independent of the concentration of the solvent extraction employed. The extract formulated with 80% ethanol in relation to other stood out by his power of acetylcholinesterase inhibition. There was a negative correlation between acetylcholinesterase activity and antioxidant activity of the extracts. Microencapsulation of extract did not cause changes in their anticholinesterase activity and antioxidant capacity. The same way, the addition of microcapsules to a powder preparation for refreshment not changed their sensory characteristics. Given the above, the preparation of microcapsules of pomegranate peel extract is a viable alternative for incorporation into various products, in order to prevent or reduce risk of Alzheimer's disease.
 
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Publishing Date
2013-03-11
 
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