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Doctoral Thesis
DOI
Document
Author
Full name
Anderson de Oliveira Souza
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2019
Supervisor
Committee
Alberici, Luciane Carla (President)
Galina Filho, Antonio
Monesi, Nadia
Sebollela, Adriano Silva
Title in Portuguese
O efeito dos Ácidos Eicosapentanóico (EPA) e Docosahexanóico (DHA) em mitocôndrias submetidas aos processos neurodegenerativos
Keywords in Portuguese
Ácidos Eicosapentanóico (EPA) e Docosahexanóico (DHA)
Drosophila melanogaster
Mitocôndria
Abstract in Portuguese
O avanço na expectativa de vida da população elevou concomitantente as manifestações de doenças neurodegenerativas, sendo Alzheimer a mais frequente. As condições clínicas mais importantes relacionadas aos pacientes acometidos por tal neurodegeneração, são as placas ?-amilóides, os emaranhados neurofibrilares e a extensa perda neuronal, ocasionadas por fatores genéticos e/ou ambientais. A alimentação pode ser um fator desencadeador de demência, pois, a baixa ou longa exposição aos pesticidas incorporados aos alimentos promovem neurodegenerações em decorrência do estresse oxidativo gerado por tais produtos químicos, desenvolvidos para alterar o metabolismo em organismos não viáveis comercialmente na agricultura, denominados como pragas. Desta forma, um sistema de neuroproteção se faz necessário para minimizar e/ou reverter os danos desencadeados por agrotóxicos incorporados em alimentos rotineiramente consumidos.
Title in English
The effect of Eicosapentaenoic (EPA) and Docosahexanoic (DHA) Acids on mitochondria submitted to neurodegenerative processes
Keywords in English
Drosophila melanogaster
Eicosapentaenoic (EPA) and Docosahexanoic (DHA) Acids
Mitochondria
Abstract in English
The advancement in the life expectancy of the population concomitantly increased the manifestations of neurodegenerative diseases, with Alzheimer being the most frequent. The most important clinical conditions related to the patients affected by such neurodegeneration are ?-amyloid plaques, neurofibrillary tangles and extensive neuronal loss, caused by genetic and / or environmental factors. Feeding can be a trigger for dementia since the low or long exposure to pesticides incorporated into foods promote neurodegenerations due to the oxidative stress generated by such chemicals, designed to alter the metabolism in non-commercially viable organisms in agriculture, known as pests In this way, a neuroprotection system is necessary to minimize and / or reverse the damage caused by pesticides incorporated into routinely consumed foods.
 
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Publishing Date
2019-08-07
 
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