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Master's Dissertation
DOI
10.11606/D.3.2007.tde-13082007-161004
Document
Author
Full name
Zhao Lili
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Wang, Shu Hui (President)
Bartoli, Julio Roberto
Catalani, Luiz Henrique
Title in Portuguese
Síntese e caracterização do copolímero tribloco anfifílico biodegradável poli(L, L-lactídeo-stat-e-caprolactona)-bloco-poli(óxido de etileno)-bloco-poli(L, L-lactídeo-stat-e-caprolactona).
Keywords in Portuguese
Copolímero biodegradável
Copolímero tribloco
Poli(ll-lactídeo-stat-e-caprolactona)
Poli(óxido de etileno)
Abstract in Portuguese
Este trabalho apresenta um estudo sobre a síntese e propriedades do copolímero poli(l,l-lactídeo-stat-e-caprolactona)-bloco-poli(óxido de etileno)-bloco-poli(l,l-lactideostat-e-caprolactona). Poli(óxido de etileno) de massa molar 20.000 u.m.a. e poli(óxido de etileno) modificado, preparado a partir de poli(glicol etilênico) de massa molar 4.000 u.m.a., foram selecionados para o processo da síntese. A reação foi feita pela polimerização por abertura de anel em massa a 120ºC usando octoanato de estanho como iniciador. A composição química de cada amostra foi determinada com auxílio de RMN-1H e RMN-13C e suas propriedades mecânicas foram verificadas e comparadas utilizando análises térmicas como DMTA, DSC, TG e a aplicação da MEV como análise complementar. A observação pelas fotos de MOLP permitiu a visualização do comportamento de nucleação dos copolímeros e as características de sua cristalinidade. Seu grau de cristalinidade e as fases cristalinas foram identificados por difração de raios X (WAXS). A biocompatibilidade do material também foi examinada pela cultura de células. Os resultados de caracterização indicam o sucesso da copolimerização, as propriedades elastoméricas e, sua não citotoxidade comprovaram a possibilidade do uso destes copolímeros como biomateriais. Contudo, o tempo prolongado de reação e baixa incorporação do monômero lactídeo ainda são questões a serem melhoradas para a viabilização do copolímero como material de implante na área biomédica.
Title in English
Synthesis and characterization of triblock anfiphilic biodegradable copolymer poly(l,l-lactide-stat-e-caprolactone)-b-poly(ethylene oxide)-b-poly(l,l-lactide-stat-e-caprolactone).
Keywords in English
Biodegradable copolymer
Poly(ethylene oxide)
Poly(ll-lactide-stat-e-caprolactone)
Triblock copolymer
Abstract in English
This work includes the study of the synthesis and characterization of the copolymer poly(l,l-lactide-stat-e-caprolactone)-b-PEG-b-poly(l,l-lactide-stat-e-caprolactone). Poly (ethylene oxide) with molar weight 20.000 and poly(ethylene oxide) modified, prepared from poly(ethylene oxide) with molar weight 4000 have been selected for this synthesis process. The reaction was done by ring-opening bulk polymerization, using stannous octoate as initiator at 120ºC. The chemical composition of samples were determined by 1H-NMR and 13C-NMR and their mechanical properties were verified using thermal analyses like DMTA, DSC and TG. Scanning electron microscopy (SEM) was applied as a complementary analysis. The pictures of polarizing optical microscopy showed us the copolymer's nucleation behaviors and their respective crystallization. The degrees of crystallinity and phase of copolymers were determined by WAXS. The biocompatibility of the copolymer was examined by cell cultivation test. The result of these analyses above indicated the success of synthesis. Their rubbery properties and non-toxicity allowed their application as biomaterial. However, the long reaction time and low incorporation of monomer of lactide might to be improved to increase its potential use in biomedical area in the future.
 
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Publishing Date
2007-08-30
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • DRUMOND, W. S., et al. Preparation and Characterization of Resorbable Hydrogel Membranes Useful for Tissue Engineering [doi:10.1002/masy.200651372]. Macromolecular Symposia [online], 2006, vol. 246247, p. 506-514.
  • DRUMOND, W. S., et al. MISCIBILITY AND THERMAL PROPERTIES OF BLENDS OF POLY(3-HYDROXYBUTYRATE) ANDPOLYETHYLENE OXIDE. In XI International Macromolecular Colloquium /6th International Symposium on Natural Polymers and Composites, GRAMADO, 2007. PROGRAM AND PROCEEDINGS OF XI International Macromolecular Colloquium /6th International Symposium on Natural Polymers and Composites.PORTO ALEGRE : UFRGS, 2007. Abstract.
  • DRUMOND, Walker Soares, et al. MISCIBILITY AND THERMAL PROPERTIES OF BLENDS OF POLY(3-HYDROXYBUTYRATE) AND POLYETHYLENE OXIDE. In XI International Macromolecular Colloquium /6th International Symposium on Natural Polymers and Composites, GRAMADO, 2007. XI International Macromolecular Colloquium /6th International Symposium on Natural Polymers and Composites.PORTO ALEGRE : UFRGS, 2007.
  • WANG, S. H., et al. SYNTHESIS AND CHARACTERIZATION OF BIODEGRADABLE TRIBLOCK COPOLYMERS OF POLY(LACTIDE-CO-CAPROLACTONE)-PEG- POLY(LACTIDE-CO-CAPROLACTONE). In PPS 2004 Américas Regional Meeting, Florianopolis, 2004. PPS 2004 Américas Regional Meeting Proceedings.São Carlos : ABPOL, 2004.
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