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Master's Dissertation
DOI
10.11606/D.3.2016.tde-12122016-095324
Document
Author
Full name
Paulo Vinícius Miyuki Yamabe
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Silva, Emilio Carlos Nelli (President)
Andrade, Aron Jose Pazin de
Burr, Karl Peter
Title in English
Study of a methodology to evaluate the severity of obstructed coronary arteries with the aid of computer simulations.
Keywords in English
Biomedical engineering
Computer simulations
Finite element method
Hemodynamics
Abstract in English
Computer simulations have become a great tool to assist the medical field. The present work is a study of a non-invasive patient-specific methodology to evaluate the hemodynamic importance of coronary stenosis using computer simulations. The severity of the lesion is evaluated by the Fractional Flow Reserve, calculated by the pressure gradient before and after the lesion. The geometry models are obtained from medical images of Computed Tomography Angiography exams, and the simulations considers the pulsatile flow and the blood as a non-Newtonian fluid. The governing equations of the blood flow are solved by using Finite Element Method applied to the numerical method called Incremental Pressure Correction Scheme, and with the aid of the libraries from the open-source software FEniCS. Computer simulations of three different patients are performed and the results are compared with the invasive FFR measurements. The methodology proposed shows to be feasible in the study and analysis of stenosed coronaries.
Title in Portuguese
Estudo de uma metodologia para avaliar a severidade de artérias coronárias obstruídas com o auxílio de simulações computacionais.
Keywords in Portuguese
Bioengenharia
Hemodinâmica
Método dos elementos finitos
Simulações computacionais
Abstract in Portuguese
Simulações computacionais tornaram-se uma excelente ferramenta para auxiliar a área médica. O presente trabalho é um estudo de uma metodologia não invasiva para avaliar a importância hemodinâmica de artérias coronárias com estenose através do uso de simulações computacionais. A severidade da lesão da artéria é avaliada através do Fractional Flow Reserve, calculado pelo gradiente de pressão antes e depois da lesão. Os modelos geométricos computacionais foram obtidos a partir de imagens médicas de exames de Angiografia por Tomografia Computadorizada e as simulações consideram o fluxo pulsátil e as propriedades não-Newtonianas do sangue. As equações governantes do fluxo de sangue são resolvidas utilizando o Método dos Elementos Finitos aplicado ao método numérico chamado Incremental Pressure Correction Scheme, e com o uso de bibliotecas do programa em código aberto FEniCS. Foram realizados simulações de três pacientes e os resultados foram confrontados com as medidas invasivas do FFR. A metodologia proposta mostrou-se viável para o estudo e análise de coronárias com estenose.
 
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Publishing Date
2016-12-13
 
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