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Master's Dissertation
DOI
10.11606/D.39.2010.tde-19082010-173945
Document
Author
Full name
Eduardo Oliveira de Souza
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Ugrinowitsch, Carlos (President)
Moriscot, Anselmo Sigari
Tricoli, Valmor Alberto Augusto
Title in Portuguese
Efeito do treinamento concorrente na expressão gênica e protéica associadas à hipertrofia muscular
Keywords in Portuguese
Crescimento muscular
Treinamento concorrente
Vias de sinalização
Abstract in Portuguese
Diversos atletas e praticantes de atividades físicas incorporam em suas rotinas de treinamento, exercícios aeróbios e de força motora simultaneamente. Contudo, essa combinação conhecida como treinamento concorrente (TC) tem demonstrado uma atenuação da resposta adaptativa da força e hipertrofia muscular. O presente estudo analisou se alguns genes e proteínas envolvidos na resposta hipertrófica e na biogênse mitocondrial do músculo esquelético poderiam explicar a atenuação da resposta adaptativa com o TC. Trinta e sete sujeitos foram divididos nos grupos: controle (C), aeróbio (TA), força (TF) e concorrente (TC) e submetidos a oito semanas de treinamento. Os resultados significantes foram: aumento na força dinâmica máxima de 270,3 (±45,5) para 320,3 (±57,0) Kg para o TF e de 268,4 (±47,6) para 315,7 (±63,5) para o TC; área de secção transversa do quadríceps de 8332,4 (±817,5) mm2 para 8849,5 (±893,3) mm2 para o TF e de 8340,8 (±1000,0) mm2 para 8996,8 (±919,5 )mm2 para o TC; o gene da mTOR demonstrou aumento significante de 1,01 (±0,10) U.A para 1,44 (±0,17) U.A no TF e redução de 1,01 (±0,15) para 0,536 (± 0,25) U.A da p70S6K1 no TC; a expressão total da proteína p70S6K1 demonstrou aumentou no grupo TC em relação ao C (1,1 (±0,2) U.A vs 0,8 (±0,3) U.A), a fosforilação da Akt no resíduo ser473 e da p70S6K1no resíduo thr389 aumentou somente no TF em relação ao C (1,3 (±0,2) U.A vs 0,9 (±0,1) U.A e 1,3 (±0,4) vs 0,8 (±0,3) U.A, respectivamente). O grupo TF e TC demonstraram adaptações similares nas variáveis de força e hipertrofia muscular apesar de algumas diferenças na resposta molecular. Esses achados indicam que na fase inicial do TC as diferenças na adaptação molecular não refletem em alterações na força e hipertrofia muscular quando comparadas ao TF
Title in English
Effect of concurrent training on gene and protein expression associated with skeletal muscle hypertrophy
Keywords in English
Concurrent training
Muscle growing
Signaling pathways
Abstract in English
Many athletes and individuals involved in physical training perform strength and endurance exercises in the same training unit. However, this combination, referred as concurrent training (CT), has shown to blunt strength and skeletal muscle growth responses. This study investigated whether some genes and proteins associated with muscle growth and mitochondrial biogenesis may explain the decreased adaptive response to CT. Thirty seven participants were divided into four groups: control (C), endurance (TA), strength (TF) and concurrent (TC) and submitted to eight weeks of training. Significant results were found in the following variables from pre to post training: maximum dynamic strength - TF from 270,3 (±45,5) to 320,3 (±57,0) Kg and TC from 268,4 (±47,6) to 315,7 (±63,5); quadriceps cross sectional area (CSA) - TF from 8332,4 (±817,5) mm2 to 8849,5 (±893,3) mm2, TC from 8340,8 (±1000,0) mm2 to 8996,8 (±919,5)mm2; mTOR gene expression increased significantly post-training only for the TF (1,01 (±0,10) A.U to 1,44 (±0,17) A.U) and p70S6K1 was significantly reduced post-training (1,01 (±0,15) to 0,536 (± 0,25) A.U) for the TC; p70S6K1 total protein content was significantly greater after TC when compared with C (1,1 (±0,2) U.A vs 0,8 (±0,3)) and phosphorylation of both Akt at ser473 and p70S6K1 at thr389 increased only after TF compared with C (1,3 (±0,2) U.A vs 0,9 (±0,1) U.A and 1,3 (±0,4) vs 0,8 (±0,3) U.A, respectively). TF and TC groups had similar improvements in muscle strength and hypertrophy, besides some differences in the molecular responses. These differences at the molecular level in early phases of the TC do not blunt muscle strength and hypertrophy adaptations compared with the TF
 
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Publishing Date
2010-08-24
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • DE SOUZA, Eduardo, et al. Molecular adaptations to concurrent training. International Journal of Sports Medicine, 2013.
  • DE SOUZA, Eduardo, et al. Multivariate analysis in the maximum strength performance. International Journal of Sports Medicine, 2012, p. 970-974.
All rights of the thesis/dissertation are from the authors
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