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Master's Dissertation
DOI
10.11606/D.42.2012.tde-22052012-094616
Document
Author
Full name
Daniella Sabino Batagello
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2012
Supervisor
Committee
Bittencourt, Jackson Cioni (President)
Marques, Maria Julia
Nogueira, Maria Ines
Title in Portuguese
Distribuição dos neurônios e campos terminais que expressam a urocortina 3 no sistema nervoso central de primata não-humano (Cebus apella).
Keywords in Portuguese
Hipotálamo
Macacos prego
Neurônios
Neuropeptídeos
Primatas
Sistema nervoso central
Abstract in Portuguese
Introdução: A urocortina 3 (UCN 3) é um neuropeptídeo pertencente a família CRF, com seletividade de ligação a receptor CRF2. Em roedores as células UCN 3 se localizam principalmente em hipotálamo e amígdala, mas o mapeamento não foi realizado em modelo de primata não-humano. Objetivo: realizar o mapeamento da distribuição da UCN 3 no sistema nervoso central na espécie Cebus apella. Material e métodos: cortes de encéfalo de animais machos foram submetidos aos métodos de imuno-histoquímica e hibridização in situ para UCN 3. Séries adjacentes foram coradas pelo método de Nissl e hematoxilina-eosina. Resultados: Células UCN 3 se localizam principalmente em regiões hipotalâmicas, amigdalóides e límbicas. Há colocalização de UCN 3/CRF no núcleo paraventricular do hipotálamo e UCN 3/insulina em células b do pâncreas. Conclusão: a distribuição de UCN 3 em primata não-humano é semelhante à de roedores.
Title in English
Distribution of neurons and terminal fields that express the Urocortin 3 in the central nervous systems of primate non-human (Cebus apella).
Keywords in English
Capuchin monkeys
Central nervous system
Hypothalamus
Neuron
Neuropeptides
Primates
Abstract in English
Introduction: Urocortin 3 (UCN 3) is a neuropeptide with 38-aa and member of the CRF peptide family, it is a selective agonist for the CRF2 receptor. UCN 3 cells in rodents showed containing- neurons found mainly in hypothalamic and amygdaloid regions. However, such mapping was not done in a non-human primate model. Objective: study the UCN 3 distribution in the brain of a monkey. Material and methods: frontal sections (40mm) were subjected to immunohistochemistry technique and in situ hybridization, Nissl and Hematoxylin-eosin staining. Results: UCN 3 cells were found mainly in the amygdaloid, limbic and hypothalamic regions. Double-labeled cells (CRF/UCN 3) were found in the PaMD and, in b cells (UCN 3/insulin) of pancreas. Conclusion: the distribution of UCN 3 in non-human primate is similar to the rodents distribution.
 
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Release Date
2017-05-23
Publishing Date
2012-06-01
 
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