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Doctoral Thesis
DOI
10.11606/T.42.2014.tde-24022015-102317
Document
Author
Full name
Christian Julian Villabona Arenas
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2014
Supervisor
Committee
Zanotto, Paolo Marinho de Andrade (President)
Matioli, Sergio Russo
Meyer, Diogo
Passos, Saulo Duarte
Waldman, Eliseu Alves
Title in English
Phylogeography of the 2013 urban outbreak of dengue virus in Guarujá, São Paulo.
Keywords in English
Dengue vírus
Epidemiology
Genetic diversity
Molecular evolution
Phylogeny
Phylogeography
Abstract in English
Dengue virus type 1 (DENV-1) was introduced in Brazil in 1986 and caused several epidemics. The first autochthonous cases of DENV-2 and DENV-3 were detected respectively in 1990 and 2000. Since then, the viruses have spread throughout Brazil and became endemic in most areas infested with Aedes aegypti. DENV-4 was isolated for the first time in 1982 in a focal epidemic in the northwestern region of the Brazilian Amazon. Later, in 2008, this serotype emerged as an important pathogen during outbreaks. The study of the historical processes that may be responsible for the contemporary geographic distributions of viruses is critical to understand viral epidemiology. However, those processes in urban scales are not well understood. 2013 was one of the worst years for dengue in the Brazils history, with 1.4 million cases, including 6,969 severe cases and 545 deaths. This project aimed to understand the dynamics of evolutionary change, origins and distributions of different viral strains in an urban setting during 2013. We expect this study to provide new perspectives for viral control.
Title in Portuguese
Filogeografia do surto urbano de 2013 da dengue em Guarujá, São Paulo
Keywords in Portuguese
Diversidade genética
Epidemiologia
Evolução molecular
Filogenia
Filogeografia
Vírus da dengue
Abstract in Portuguese
O vírus da dengue tipo 1 (DENV-1) foi introduzido no Brasil em 1986 e foi responsável por numerosas epidemias. Os primeiros casos autóctones do DENV-2 e DENV-3 foram detectados respectivamente em 1990 e 2000. Desde então, o vírus ter se espalhado por todo o Brasil e tornou-se endêmico na maioria das áreas infestadas com Aedes aegypti. DENV-4 foi isolado pela primeira vez em 1982, em uma epidemia focal na região noroeste da Amazônia brasileira. Porem, este sorotipo somente emergiu como um importante patógeno durante os surtos de 2008. O estudo dos processos históricos que podem ser responsáveis para as distribuições geográficas contemporâneas do vírus é fundamental para compreender a epidemiologia viral. No entanto, esses processos em escalas urbanas não são bem compreendidos. 2013 foi um dos piores anos para a dengue na história do Brasil, com 1,4 milhões de casos, incluindo 6.969 casos graves e 545 mortes. Este projeto teve como objetivo compreender a dinâmica de mudança evolutiva, origens e distribuições de diferentes cepas virais em um cenário urbano em 2013. Esperamos que este estudos contribua com novas perspectivas para o controle viral.
 
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Release Date
2017-02-23
Publishing Date
2015-02-24
 
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