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Master's Dissertation
DOI
10.11606/D.42.2013.tde-14032014-155032
Document
Author
Full name
Cíntia Scucuglia Heluany
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Yamanouye, Norma (President)
Gonçalves, Alyne Simões
Yan, Chao Yun Irene
Title in Portuguese
Sistema nervoso simpático na ativação da glândula submandibular e parótida de camundongos.
Keywords in Portuguese
Adrenoreceptores
Glândula parótida
Glândula submandibular
Proteínas
Sistema nervoso simpático
Abstract in Portuguese
Dados da literatura mostram que a inervação simpática possui papel apenas na síntese e secreção das proteínas da saliva. Neste trabalho mostramos que após o tratamento crônico com reserpina, uma droga simpatolítica, houve alteração na síntese de diferentes proteínas em glândulas submandibulares e parótidas relacionadas com vários processos biológicos e a posterior administração de agonistas de adrenoceptores reverteu esses efeitos. Além disso, na glândula parótida, a estimulação da inervação simpática é importante para o processo de exocitose das proteínas secretadas. Esses resultados sugerem que a inervação simpática possui um importante papel para a funcionalidade das glândulas salivares de camundongos, isto é, mantendo estas glândulas em constante estado de ativação, regulando a síntese de diferentes proteínas dessas glândulas ou promovendo a exocitose de proteínas da saliva. Além disso, os resultados mostram que a inervação simpática atua de maneira diferente nas glândulas submandibulares e parótidas de camundongos.
Title in English
Sympathetic outflow on activation of the mouse submandibular and parotid glands.
Keywords in English
Adrenoceptor
Parotid gland
Proteins
Submandibular gland
Sympathetic nervous system
Abstract in English
Data in literature show that sympathetic outflow has a role only in stimulating synthesis and secretion of the saliva proteins in mammals. We show that after chronic treatment with reserpine, a sympatholytic drug, there were changes in the synthesis of different proteins in submandibular and parotid glands associated with various biological processes and subsequent administration of adrenoceptor agonists reversed these effects. Furthermore, in the parotid gland, stimulation of the sympathetic outflow is important to the process of exocytosis of secretory proteins. These results suggest that sympathetic outflow plays an important role for the functionality of the mouse salivary glands, namely, keeping these glands in a constant activated stage, regulating the synthesis of different proteins in these glands or promoting the exocytosis of saliva proteins. Furthermore, these results show that the sympathetic outflow acts differently in the mouse.
 
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Publishing Date
2014-03-29
 
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