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Master's Dissertation
DOI
10.11606/D.42.2013.tde-14032014-175314
Document
Author
Full name
Juliana da Costa Florim
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Santos, Marinilce Fagundes dos (President)
Freitas, Vanessa Morais
Hassimotto, Neuza Mariko Aymoto
Title in Portuguese
Emprego de nanopartículas lipídicas sólidas contendo extrato de semente de uvas para aceleração da cicatrização de feridas cutâneas em camundongos diabéticos.
Keywords in Portuguese
Antioxidantes
Cicatrização
Diabetes mellitus
Estresse oxidativo
Nanotecnologia
Proantocianidinas
Abstract in Portuguese
O estresse oxidativo causado pela hiperglicemia desempenha um importante papel no desenvolvimento e progressão do diabetes mellitus (DM) e suas complicações, como a cicatrização deficiente de feridas. Nós avaliamos os efeitos da administração tópica de nanopartículas lipídicas sólidas (NLS) contendo extrato de semente de uva sobre a cicatrização de feridas cutâneas de camundongos controles e diabéticos. Os resultados obtidos na caracterização do nosso modelo experimental mostraram um atraso no fechamento da ferida dos animais diabéticos, acompanhado de uma resposta inflamatória atrasada, mas persistente, bem como um grau significativo de peroxidação lipídica na derme dos animais diabéticos. O tratamento tópico com gel, com a NLS branca e com a NLS contendo extrato de semente de uva foram capazes de recuperar o atraso na cicatrização da ferida diabética e atenuar a peroxidação lipídica, de forma mais acentuada com a aplicação da NLS branca e com a NLS associada ao extrato de semente de uva, comprovando a suas propriedades antioxidantes.
Title in English
Effects of solid lipid nanoparticles containing grape seed extract in diabetic mice cutaneous wound healing.
Keywords in English
Antioxidants
Diabetes mellitus
Nanotechnology
Oxidative stress
Proanthocyanidins
Wound healing
Abstract in English
Oxidative stress caused by hyperglycemia plays an important role in the development and progression of diabetes mellitus (DM) and its complications, such as impaired wound healing. We evaluated the effects of topical administration of solid lipid nanoparticles (SLN) containing grape seed extract on skin wound healing in control and diabetic mice. The results showed a retarded wound closure in diabetic animals, accompanied by a delayed but persistent inflammatory reaction, as well as a significant degree of lipid peroxidation in the dermis. Topical treatment with gel (vehicle), white NLS and NLS associated with grape seed extract were able to efficiently accelerate wound closure and attenuate lipid peroxidation, especially with the application of white NLS and NLS containing Vitaflavan®, proving its antioxidant properties.
 
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Publishing Date
2014-03-29
 
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