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Doctoral Thesis
DOI
10.11606/T.42.2017.tde-14032017-140028
Document
Author
Full name
Rodrigo Medeiros de Souza
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Marinho, Claudio Romero Farias (President)
Bevilacqua, Estela Maris Andrade Forell
Ferreira, Marcelo Urbano
Santi, Sílvia Maria Fátima di
Silva, Márcia Guimarães da
Title in Portuguese
Alterações histopatológicas placentárias associadas à infecção por Plasmodium vivax em gestantes do Vale do Alto Juruá.
Keywords in Portuguese
Plasmodium vivax
Gestação
Malária
Patologia
Placenta
Abstract in Portuguese
Poucos estudos descrevem os aspectos histopatológicos da malária placentária em áreas de transmissão instável para Plasmodium vivax. Pretendemos identificar as alterações histopatológicas e suas intensidades, avaliar o impacto de fatores clínicos e epidemiológicos e a associação dos níveis de citocinas e anafilatoxinas relacionadas à malária placentária causada por Plasmodium vivax. Um estudo longitudinal foi realizado em Cruzeiro do Sul (Acre), com seleção de gestantes não infectadas e infectadas. A prevalência de malária placentária detectada por histologia foi de 13,5%. Não foram encontradas evidências microscópicas da adesão por P. vivax no sinciciotrofoblasto, porém esta espécie ocasionou danos placentários semelhantes aos observados na malária gestacional por P. falciparum, porém com intensidade menor do que a observada em áreas de alta transmissão. As alterações ocasionadas podem ser decorrentes de distúrbios locais e sistêmicos que contribuem para um desfecho desfavorável durante a malária gestacional e placentária ocasionadas por P. vivax.
Title in English
Histopathological placental changes associated with Plasmodium vivax infection in pregnant women from Alto Jurua Valley.
Keywords in English
Plasmodium vivax
Malaria
Pathology
Placenta
Pregnancy
Abstract in English
Few studies describe histopathological aspects of placental malaria in unstable transmission areas for Plasmodium vivax. The objectives of the present work were to identify histopathological alterations and their intensities by assessing the impact of clinical and epidemiologic factors and the association of cytokines and anaphylatoxin levels related to gestational and placental malaria caused by the Plasmodium vivax. A longitudinal study was performed in Cruzeiro do Sul (Acre) by selecting non-infected and infected pregnant. No microscopic evidence of adhesion were found for that species in the syncytiotrophoblast, but this species cause similar placental damage to those seen in P. falciparum malaria, but with lower intensity than that observed in high transmission areas. Finally, the alterations caused in the placental environment can concomitantly result from local and systemic disturbances that jointly contribute to an unfavorable outcome upon the gestational and placental malaria caused by the P. vivax.
 
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Release Date
2019-05-22
Publishing Date
2017-05-22
 
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