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Master's Dissertation
DOI
10.11606/D.42.2016.tde-17082016-115850
Document
Author
Full name
Natália Soares Ferreira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Véliz, Mauro Javier Cortez (President)
Batista, Patrícia Xander
Popi, Ana Flavia
Title in Portuguese
Papel das células B-1 na infecção por Leishmania (L.) amazonensis.
Keywords in Portuguese
L. (L.) amazonensis
Células B-1
Macrófagos
Vacúolo parasitóforo
Abstract in Portuguese
Parasitos do gênero Leishmania causam um espectro de doenças chamadas de leishmaniose. Para compreender de melhor forma a imunobiologia da Leishmania, o estudo de outras células envolvidas no processo de infecção do parasito se torna importante. As células B-1 são encontradas principalmente nas cavidades peritoneal e pleural, tendo como característica a capacidade de se diferenciar em células fagocíticas. Este trabalho teve como objetivo avaliar o papel das células B-1 na infecção por L. (L.) amazonensis. Os resultados mostraram que, assim como os macrófagos, os B-1CDPs são infectados pelo mecanismo de fagocitose e permitem a multiplicação da Leishmania no seu interior. Além disso, os vacúolos parasitóforos formados nos B-1CDPs apresentaram ser maiores do que dos macrófagos. Portanto, os dados com B1CDPs sugerem que estas células podem possuir um papel relevante na infecção por L. (L.) amazonensis, podendo ser considerados células hospedeiras importantes durante a infecção devido à incapacidade de responder de maneira eficaz para a eliminação dos parasitos.
Title in English
Role of B-1 cells in the infection by Leishmania (L.) amazonensis
Keywords in English
L. (L.) amazonensis
B-1 cells
Macrophages
Parasitophorous vacuole
Abstract in English
The genus Leishmania parasites cause a spectrum of diseases called leishmaniasis. To better understand the immunobiology of Leishmania, the study of other cells involved in parasite infection process becomes important. The B-1 cells are found predominantly in the peritoneal and pleural cavities, whose feature consist on an ability to differentiate into phagocytic cells. This study aimed to evaluate the role of B-1 cells in the infection by L. (L.) amazonensis. The results showed that, like macrophages, B-1CDPs are infected by a mechanism of phagocytosis and allow the multiplication of Leishmania within. Furthermore, the parasitophorous vacuoles in the B-1CDPs showed to be larger than those formed in the macrophages. Therefore, B1CDPs can have an important role in infection by L. (L.) amazonensis and can be considered important host cells during infection due to inability to respond effectively to the elimination of parasites.
 
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Publishing Date
2016-08-17
 
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