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Master's Dissertation
DOI
10.11606/D.42.2015.tde-09122015-064908
Document
Author
Full name
Milena Telles
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2015
Supervisor
Committee
Viel, Tânia Araújo (President)
Longo, Beatriz Monteiro
Munhoz, Carolina Demarchi
Title in Portuguese
Relação entre sistema colinérgico e formação de reserva cognitiva após treino de atenção semanal em camundongos infundidos cronicamente com peptídeo B-amiloide.
Keywords in Portuguese
Neurodegeneração
Resiliência cerebral
Sistema colinérgico
Treino semanal
Abstract in Portuguese
O sistema colinérgico está sabidamente envolvido com processos cognitivos. Em trabalho recente mostramos que a infusão do peptídeo A promoveu neurodegeneração e redução da memória de ratos. O treino semanal dos animais em equipamento de esquiva ativa recuperou o desempenho na tarefa e aumentou a densidade de receptores nicotínicos α7 em áreas relacionadas à memória. No presente trabalho, o antagonismo de α7 com metilicaconitina (MLA), em camundongos, promoveu perda cognitiva, porém a recuperação com o treino foi parcial. A infusão conjunta de βA e MLA causou perda da memória, mas essa não foi revertida com o treino semanal. Os animais com MLA apresentaram aumento da atividade da acetilcolinesterase (AChE) e aumento de BDNF, que poderia ser relacionado à resiliência a injúrias. Porém, animais com A e MLA apresentaram aumento da atividade da AChE e redução de BDNF, sugerindo perda dos mecanismos de neuroproteção deflagrados por α7. Com isso, sugere-se que α7 tenha um papel determinante na recuperação da memória e resiliência tecidual, frente à neurodegeneração.
Title in English
Role of cholinergic system in formation of cognitive reserve, after attetion trainning of mice chronically infused with amyloid- beta peptide.
Keywords in English
Attention training
Brain resilience
Cholinergic system
Neurodegeneration
Abstract in English
Cholinergic system plays an important role in cognitive processes. In a recent work we showed that infusion of Aβ promoted neurodegeneration and reduction of memory of rats. Week training of animals in active avoidance shuttle box recovered their performance and increased the density of α7 nicotinic receptors in brain areas related to memory. In the present work, infusion of the α7 antagonist methyllycaconitine (MLA), in mice, caused cognitive impairment, but memory recover with week training was partial. Infusion of βA together with MLA promoted memory loss, but this was not recovered with the week training. MLA infused mice presented increase in acetylcholinesterase (AChE) activity and increase in BDNF, which could be related to resilience to tissue injuries. However, animals infused with βA and MLA showed increase in AChE activity and reduction of BDNF, suggesting loss of neuroprotection mechanisms triggered by α7. It is suggested that α7 has a determinant role in memory recover and brain resilience, in neurodegenerative processes.
 
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Publishing Date
2015-12-09
 
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