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Master's Dissertation
DOI
10.11606/D.42.2013.tde-17062014-105349
Document
Author
Full name
Marilia Silva de Albuquerque
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Viel, Tânia Araújo (President)
Moreira, Karin di Monteiro
Torrão, Andréa da Silva
Title in Portuguese
Caracterização da memória e de marcadores colinérgicos ao longo do envelhecimento de ratos.
Keywords in Portuguese
Canais iônicos
Envelhecimento
Membrana plasmática
Memória
Ratos
Receptores colinérgicos
Abstract in Portuguese
O sistema colinérgico possui papel importante na modulação dos processos de aprendizagem e memória. Nesse trabalho, avaliamos a evocação da memória de ratos de 3, 6, 12, 18 e 22 meses em esquiva inibitória e, também, analisamos a densidade dos receptores nicotínicos a7 e da subunidade b2 no hipocampo, além de enzimas colinérgicas, a colina acetiltransferase e a acetilcolinesterase. Os grupos com 18 e 22 meses apresentaram uma redução na evocação da memória de longa duração (MLD) e um aumento na densidade de receptores a7 nas piramidais de CA3 e nas células de PoDG, este apenas em 22 meses. Em contrapartida, os demais marcadores colinérgicos estavam inalterados nas diferentes idades. Assim, a redução na evocação da MLD dos animais de 18 e 22 meses acompanhada do aumento na densidade de receptores a7 pode ser caracterizada como: 1) estratégia adaptativa do envelhecimento (plasticidade colinérgica em neurônios glutamatérgicos) ou 2) modulação nos interneurônios GABAérgicos desencadeando, assim, um bloqueio no processamento da informação e o declínio da memória.
Title in English
Characterization of memory and cholinergic markers during the aging of rats.
Keywords in English
Aging
Cholinergic receptors
Ion channels
Memory
Plasma membrane
Rats
Abstract in English
The cholinergic system plays an important role in modulating learning and memory. In this work, we evaluated the memory recall of 3, 6, 12, 18 and 22 months old rats in passive avoidance apparatus and we also evaluated, in the hippocampus, the density of a7 nicotinic receptors, b2 subunit receptor, choline acetiltransferase (ChAT) and acetilcholinesterase (AChE). The 18 and 22 months old showed a deficit in long-term memory (LTM) and an increase in a7 density in CA 3 pyramidals cells (py CA3) and polymorphic cells of Dentate Gyrus (PoDG).On the other hand, the other cholinergic markers were unchanged with aging. Thus, the deficit in LTM observed in 18 and 22 months combined with the increased a7 receptors in PoDG and py CA 3 in the hippocampus could be explained by: 1) as an adaptative strategy of aging (cholinergic plasticity in glutamatergic neurons) or 2) as a modulation in GABA interneurons triggering inhibition in the memory evocation.
 
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Publishing Date
2014-06-17
 
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