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Master's Dissertation
DOI
10.11606/D.42.2008.tde-28052008-163556
Document
Author
Full name
Núbia de Souza Lobato
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Fortes, Zuleica Bruno (President)
Machado, Ubiratan Fabres
Neves, Mario Fritsch Toros
Title in Portuguese
Efeito do tratamento com metformina sobre alterações vasculares em modelo de resistência à insulina.
Keywords in Portuguese
Metformina
Obesidade
Reatividade vascular
Resistência à insulina
Abstract in Portuguese
Avaliou-se a participação do óxido nítrico (NO), do fator hiperpolarizante derivado do endotélio (EDHF), dos produtos da ciclooxigenase (COX), das espécies reativas de oxigênio (EROs) e o efeito do tratamento com metformina (Met) nas alterações vasculares em ratos com obesidade induzida por glutamato monossódico (MSG). O tratamento com Met corrigiu alterações metabólicas em ratos MSG, reduzindo o acúmulo de gordura visceral, corrigindo a resistência à insulina, a hiperinsulinemia e a dislipidemia. Ratos MSG apresentaram aumentada resposta contrátil e diminuída sensibilidade à Ach, associadas a alterações na via do NO, do EDHF, dos produtos da COX e das EROs. Ratos MSG com 16 semamas apresentaram hiperresponsividade ao nitroprussiato de sódio, que foi mantida nos ratos tratados com Met. A Met corrige as alterações da resposta vascular atuando sobre o NO e o EDHF, reduzindo a geração de EROs e interferindo na resposta do músculo liso vascular, mantendo a hiperresponsividade ao NO.
Title in English
Effect of metformin treatment upon vascular alterations in insulin resistance model (rat obesity).
Keywords in English
Insulin resistance
Metformin
Obesity
Vascular reactivity
Abstract in English
The role of the nitric oxide (NO), the endothelium derived hyperpolarizing factor (EDHF), the ciclooxygenase (COX) products and the reactive oxygen species (ROS), as well as the effect of metformin (Met) treatment on the vascular alterations in rat model of obesity induced by monosodium glutamate (MSG) were evaluated. Met treatment corrected metabolic alterations in MSG, reducing fat accumulation, correcting dyslipidemia, insulin resistance and hyperinsulinemia. MSG rats had an increased response to norepinephrine and decreased sensitivity to acetilcholine, which were associated with alterations in NO, COX products and ROS. Sixteen-week-old MSG rats presented hyperresponsiveness to sodium nitroprusside, which was preserved in Met-treated group. Met corrects the alterations of the vascular reactivity acting on NO and EDHF, and decreasing the ROS generation, besides its effect on the vascular smooth muscle response, preserving the hyperresponsiveness to NO.
 
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Publishing Date
2008-06-18
 
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