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Doctoral Thesis
DOI
10.11606/T.42.2015.tde-02062015-151552
Document
Author
Full name
Rosana Fátima Dantas Ferreira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2015
Supervisor
Committee
Cipolla Neto, Jose (President)
Carpinelli, Angelo Rafael
Peres, Mario Fernando Prieto
Pinato, Luciana
Title in Portuguese
Efeitos da reposição terapêutica central de melatonina em animais pinealectomizados - implicações no comportamento alimentar e peso corporal.
Keywords in Portuguese
Comportamento alimentar
Injeção intracerebroventricular
Melatonina
Pinealectomia
Resistência à insulina
Abstract in Portuguese
A melatonina é um hormônio que possui ritmos circulatórios robustos e previsíveis. Em animais pinealectomizados a concentração plasmática de melatonina é abolida e acompanha alterações fisiológicas como resistência à insulina e desequilíbrio entre requerimento e mobilização energética do tecido adiposo. Este estudo objetivou avaliar os efeitos da suplementação de melatonina central, através de injeção intracerebroventricular (ICV). Os resultados obtidos indicam que a pinealectomia, provoca um aumento do consumo alimentar e um considerável aumento de peso. Mostrou-se, ainda, que a reposição ICV de melatonina é capaz de provocar a diminuição do consumo alimentar, assim como uma diminuição expressiva do peso corporal. Observou-se, também, que a administração de melatonina nos animais controles regularizam o peso corpóreo, impedindo o aumento de peso próprio do avançar da idade e que a melatonina foi um agente importante na redução de gordura corporal.
Title in English
Effects of therapeutic central replacement of melatonin in pinealectomized animals - implications on feeding behavior and body weight.
Keywords in English
Feeding behavior
Insulin resistance
Intracerebroventricular injection
Melatonin
Pinealectomy
Abstract in English
Melatonin is a hormone with robust and predictable rhythms being a strong synchronizer for the expression of several physiological processes. But in pinealectomized rats plasma concentration of melatonin is abolished, leading to physiological changes such as insulin resistance and imbalance between energy requirement and mobilization from adipose tissue. The aim of the study was to evaluate the effects of intracerebroventricular supplementation of melatonin. We studied food intake, weight gain and peripheral insulin sensitivity. The results obtained indicate that the pinealectomy caused an increase in food consumption and a considerable weight gain. Furthermore, icv melatonin replacement in these animals counteracted both effects. It was observed also that melatonin in control animals regulates body weight, preventing weight gain characteristic of aging. Finally, it was also observed that melatonin-induced decrease in body weight is due to a reduction of fat adipose tissues.
 
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Release Date
2017-06-02
Publishing Date
2015-06-03
 
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