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Master's Dissertation
DOI
10.11606/D.42.2007.tde-03062008-124025
Document
Author
Full name
Camilla Ferreira Wenceslau
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Rossoni, Luciana Venturini (President)
Souza, Maria Oliveira de
Xavier, Fabiano Elias
Title in Portuguese
Efeito da administração crônica a longo prazo de ouabaína sobre a pressão arterial e a reatividade vascular de artérias mesentéricas de resistência de rato: possíveis mecanismos envolvidos.
Keywords in Portuguese
Artérias mesentéricas de resistência
Endotélio
Hipertensão
Na+K+-ATPase
Ouabaína
Reatividade vascular
Abstract in Portuguese
A ouabaína (OUA) promoveu hipertensão arterial (HA) após 5, 10 e 20 semanas de tratamento e modificou a função vascular de artérias mesentéricas de resistência (AMR). O tratamento por 5 semanas com OUA aumentou o óxido nítrico (NO) e a expressão protéica da isoforma neuronal de óxido nítrico (nNOS), ao passo que diminuiu os prostanóides vasoconstritores. Além disso, reduziu a expressão protéica da Cu-Zn superóxido dismutase (SOD) e aumentou a atividade funcional da Na+K+-ATPase. Já o tratamento por 10 semanas com OUA aumentou NO e prostanóides vasodilatadores, enquanto diminuiu a expressão protéica da nNOS e da COX-2. O tratamento por 20 semanas reduziu o NO e a expressão protéica da nNOS. Porém, aumentou o ânion superóxido, o tromboxano A2 e a expressão protéica de ambas: a SOD e a COX-2. Em conclusão, o tratamento com OUA promoveu HA e alterações funcionais em AMR, sendo estas dependentes do tempo analisado, pois no tratamento durante 5 e 10 semanas estas alterações não contribuem para a manutenção da HA, enquanto que o tratamento durante 20 semanas contribui.
Title in English
Time-dependent effect of chronic ouabain administration in rats on blood pressure and vascular reactivity in mesenteric resistance arteries: the possible mechanisms involved.
Keywords in English
Endothelium
Hypertension
Mesenteric resistance arteries
Na+K+-ATPase
Ouabain
Vascular reactivity
Abstract in English
Ouabain treatment (OUA) developed hypertension after 5, 10 and 20 weeks and modified the vascular function in mesenteric resistance arteries (MRA). 5-weeks treatment with OUA increased nitric oxide (NO) and neuronal isoform of nitric oxide (nNOS) protein expression. On the other side, this treatment reduced vasoconstrictors prostanoids. Besides decreased Cu-Zn superoxide dismutase (SOD) protein expression and increased functional activity of Na+K+-ATPase. 10-weeks treatment enhance NO and vasodilators prostanoids but reduced both nNOS and COX-2 protein expression. 20-weeks treatment reduced NO and nNOS protein expression. Nevertheless increased anion superoxide, tromboxan A2 and both SOD and COX-2 protein expression. In conclusion, OUA treatment induced HA and functional alterations in MRA that are time-dependents, because in 5 and 10 weeks of treatment these alterations are not likely to maintenance of HA, but the changes observed in the treatment during 20 weeks contributes.
 
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Publishing Date
2008-06-11
 
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