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Doctoral Thesis
DOI
10.11606/T.42.2017.tde-10052017-105538
Document
Author
Full name
Gabriel Nasri Marzuca Nassr
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Curi, Rui (President)
Boaventura, Maria Fernanda Cury
Hirabara, Sandro Massao
Lancha Junior, Antonio Herbert
Rodrigues, Alice Cristina
Title in Portuguese
Vias de síntese e degradação de proteínas no músculo esquelético após atrofia por desuso: modulação por ácidos graxos ômega-3.
Keywords in Portuguese
Atrofia muscular
DHA
EPA
FAT-1
Óleo de peixe
Suspensão das patas traseiras
Abstract in Portuguese
Avaliamos no presente estudo: 1) os efeitos do desuso das patas traseiras de ratos por duas semanas sobre as vias de sinalização de síntese e degradação de proteínas no músculo sóleo e a administração de óleos de peixe ricos em eicosapentaenóico (EPA) ou docosaexaenóico (DHA) e 2) as alterações induzidas pelo desuso no músculo sóleo em camundongos FAT-1. Concluímos que, apesar da variação pequena na razão ácidos graxos ômega-6/ômega-3, efeitos significativos da oferta aumentada de ácidos graxos ômega-3 foram observados na área de seção transversa e vias de sinalização relacionadas à síntese e degradação de proteínas no músculo sóleo nos dois protocolos.
Title in English
Protein synthesis and degradation signaling in skeletal muscle after muscle disuse atrophy: modulation by omega-3 fatty acids.
Keywords in English
DHA
EPA
FAT-1
Fish oil
Hindlimb suspension
Muscle atrophy
Abstract in English
We investigated herein: 1) the effects skeletal muscle disuse atrophy induced by two-week hind limb suspension (HS) on protein synthesis and degradation signaling in soleus muscle and the administration of either eicosapentaenoic (EPA) or docosahexaenoic (DHA)-rich fish oil supplementation, and 2) the changes induced by hind limb disuse on soleus muscle of Fat-1 transgenic mice. We concluded that, in spite of the small variation in the omega-6/omega-3 fatty acid ratio, significant effects of the increased omega-3 fatty acid levels were observed on the CSA and signaling pathways associated with soleus muscle protein synthesis and degradation in both experimental protocols.
 
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Release Date
2019-05-10
Publishing Date
2017-05-10
 
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