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Master's Dissertation
DOI
https://doi.org/10.11606/D.42.2012.tde-18092012-090242
Document
Author
Full name
Barbara Falquetto Barna
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2012
Supervisor
Committee
Moreira, Thiago dos Santos (President)
Canteras, Newton Sabino
Zoccal, Daniel Breseghello
Title in Portuguese
Estudo da ativação de áreas hipotalâmicas e do tronco encefálico após o exercício físico agudo em ratos.
Keywords in Portuguese
Cardiorrespiratório
Exercício físico
Ratos
Sistema respiratório
Tronco encefálico
Abstract in Portuguese
Durante o exercício físico existe uma intensa mobilização encefálica promovendo a tensão muscular, alterações circulatórias e respiratórias. A hipótese é que áreas encefálicas envolvidas no controle cardiorrespiratório participam no exercício físico agudo. Foram utilizados ratos Wistar divididos em grupo exercício e grupo repouso. Houve redução dos níveis de PaCO2 e aumento da PaO2, sem alteração de pH, bicarbonato e lactato após o exercício. Houve aumento da imunorreatividade à Fos em relação ao grupo controle no NTSc, no NTSm, no BVLr, incluindo C1, no NPBL, no CPB, no KF, na PeF/HL, no HDM e no NPV. Ademais, os neurônios quimiossensíveis do NRT ativados representam 18% do total e recebem projeções da região PeF/HL. Neste trabalho, mostramos que após um exercício físico ocorre uma intensa ativação de possíveis áreas encefálicas importantes para o controle cardiorrespiratório, além dos neurônios quimiossensíveis do NRT envolvidos no controle respiratório durante o exercício físico, através da participação do comando central de vias hipotalâmicas.
Title in English
Pontomeduallry and hypothalamic areas activated after exercise in rats.
Keywords in English
Cardiorespiratory
Mice
Physical exercise
Respiratory System
Stem brain
Abstract in English
During exercise there is an intense brain mobilization promoting muscle tension, respiratory and circulatory changes. We tested the hypothesis that brain areas involved in cardiorespiratory control could be activated during the acute physical exercise. Wistar rats were divided into exercise group and non-exercise group. There was decrease in PaCO2, increase in PaO2 and no changes in pH, bicarbonate and lactate after exercise. Increase in Fos immunoreactivity in cNTS, mNTS, VLM, C1 included, LPBN, KF, PeF/LH and PVN. Moreover, the chemosensitivity RTN neurons accounted for 18% of the total and receive projections from the PeF/LH. In the present study, we showed that after running acute exercise there is an intense activation of brain areas important for the cardiorespiratory control. Besides that, the chemosensitivity neurons of the RTN are activated after acute running exercise, showing that these particular subset of neurons have a role of the respiratory control during exercise, through the involvement of the "central command" of the hypothalamus.
 
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Publishing Date
2012-10-19
 
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