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Master's Dissertation
DOI
10.11606/D.42.2010.tde-20052010-145421
Document
Author
Full name
Natalie Carolina de Castro
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Lima, Fabio Bessa (President)
Alaniz, Miriam Helena Fonseca
Cipolla Neto, Jose
Title in Portuguese
O volume celular do adipócito contribui para a heterogeneidade funcional do tecido adiposo branco
Keywords in Portuguese
Adipócito
Gordura epididimal
Gordura netro-peitoneal
Gordura sub cutânea
Metabolismo adipócito
Tecido adiposo branco
Abstract in Portuguese
O tecido adiposo já foi considerado um tecido metabolicamente pouco ativo, no entanto, os mais recentes avanços mostram que ele desempenha uma função importante no controle da homeostase energética. Baseado neste conceito, este trabalho objetivou caracterizar o perfil morfológico e metabólico de adipócitos isolados de três diferentes coxins adiposos, subcutâneo, peri-epididimal, retro-peritoneal (SC, PE e RP respectivamente). Os adipócitos dos diferentes coxins foram coletados e submetidos a análise morfológica, aos ensaios metabólicos e análise da expressão de enzimas envolvidas no metabolismo lipídico e glicídico. Os resultados mostraram diferença estatisticamente significativa no volume dos adipócitos das três regiões entre si (p<0,05), maior capacidade lipogênica dos adipócitos RP. Paralelamente, o tecido SC, mostrou maior expressão de enzimas envolvidas na via lipogênica (p< 0,05; SC vs PE e RP).
Title in English
The adipocyte size contributes to the functional heterogeneity of white adipose tissue
Keywords in English
Adipocyte
Adipocyte metabolism
Epidymal fat
Retroperitoneal fat
Sub-cutaneous fat
White Adipose Tissues
Abstract in English
The adipose tissue was considered to be a little active metabolic tissue, however, the most recent advances show that it plays an important function in the control of the energy homostasis. Based on this concept, this work aimed to characterize the morphology and metabolism of isolated adipocytes of three different depots, like: subcutaneous, periepididymal, retroperitoneal (SC, PE and RP) . The adipocytes of the different depots had been collected and submitted to morphologic analysis, metabolic assays and to analysis of the enzymes expressions involved on lipids and glucose metabolism. The results showed statistical significant difference on volume of the adipocytes among the three different depots (p< 0, 05), high lipogenic capacity of RP adipocytes and higher expression of proteins involved in lipogenic patways of SC adipocytes (p<0, 05).
 
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Publishing Date
2010-06-07
 
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