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Doctoral Thesis
DOI
10.11606/T.42.2011.tde-23012012-164619
Document
Author
Full name
Mark Thomaz Ugliara Barone
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2011
Supervisor
Committee
Barreto, Luiz Silveira Menna (President)
Cipolla Neto, Jose
Martins, Anna Karenina Azevedo
Moura, Sonia Maria Guimarães Pereira Togeiro de
Vivolo, Sandra Roberta Gouvea Ferreira
Title in Portuguese
Ciclo vigília/sono em portadores de diabetes mellitus tipo 1.
Keywords in Portuguese
Ciclo vigília/sono
Cronobiologia
Diabetes mellitus tipo 1
Melatonina
Soro
Abstract in Portuguese
O objetivo do presente estudo foi avaliar possíveis relações entre o diabetes mellitus tipo 1 (DM1) e controle glicêmico, e o ciclo vigília/sono. Participaram 18 voluntários com DM1 (idade: 26,3±5,1), sem complicações, não obesos, sem alterações no sono; e 9 no grupo controle (idade: 28,8±5,3). Os dados foram coletados através de: diário de sono e de glicemia, actímetria (Tempatilumi), polissonografia, 6-sulfatoximelatonina, questionário de Epworth, e sensor de glicose durante a polissonografia nos DM1. A associação entre controle glicêmico e o ciclo vigília/sono foi evidenciada. A duração inadequada, a baixa qualidade, a fragmentação do sono e a secreção reduzida de melatonina, possivelmente, favoreceram um pior controle glicêmico em DM1. Por outro lado, indivíduos DM1, com melhor controle glicêmico, podem se beneficiar de maior secreção de melatonina noturna e menor fragmentação e latência do sono. O controle mais adequado, potencialmente, regulariza o ciclo vigília/sono e previne ou retarda o desenvolvimento de complicações crônicas.
Title in English
Sleep/wake cycle in individuals with type 1 diabetes mellitus.
Keywords in English
Chronobiology
Melatonin
Serum
Sleep/wake cycle
Type 1 diabetes mellitus
Abstract in English
The aim of the present study was to evaluate the association of type 1 diabetes mellitus (T1DM) and glycemic control with the sleep/wake cycle. Eighteen T1DM volunteers and 9 control subjects, non-obese, without chronic complications, and no sleep disorders participated. Data were collected with sleep and glycemia log, actigraphy (Tempatilumi), polysomnography, 6-sulphatoxymelatonin, Epworth questionnaire, and glucose sensor during the polysomnography night for T1DM. The association between glycemic control and sleep/wake cycle was observed. The inadequate duration, poor quality, and fragmented sleep besides the reduced melatonin secretion possibly favored a worse glycemic control in T1DM. On the other hand, we understand that T1DM individuals with better glycemic control may benefit from increased melatonin secretion and less sleep fragmentation and latency. Therefore, a better glycemic control potentially regulates the sleep/wake cycle and prevents or delays the development of chronic complications.
 
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Publishing Date
2012-02-13
 
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