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Master's Dissertation
DOI
10.11606/D.46.2017.tde-22112017-141600
Document
Author
Full name
Yuniel Tejeda Mazola
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Santos, Alcindo Aparecido dos (President)
Oliveira, Kleber Thiago de
Silva, Márcio Santos da
Title in Portuguese
Síntese de Derivados de seleno-aminoácidos e estudos preliminares de sua atividade antioxidante
Keywords in Portuguese
Estudo fotofísico
Morita-Baylis-Hillman
Organocalcogênios
Sondas fluorescentes
Abstract in Portuguese
Há no organismo humano Glutationas peroxidases (GPx), muitas dessas responsáveis por proteger as células contra espécies reativas de oxigênio (ROS, do inglês Reactive Oxygen Species), cuja detecção pode ser realizada por sondas fluorescentes. Tais sondas podem conter em sua estrutura átomos de selênio ou telúrio. Esses calcogênios apresentam várias propriedades, dentre elas a suscetibilidade a processos oxidativos, que podem levar a mecanismos de transferência eletrônica fotoinduzida (PET), promovendo um sistema on/off de fluorescência na molécula. Sendo assim os derivados de selenoaminoácidos e sondas fluorescentes contendo calcogênios podem ser empregados tanto na eliminação de espécies reativas de oxigênio como na sua detecção. O presente trabalho propôs a síntese de derivados de selenoaminoácidos, via reações do tipo Morita-Baylis-Hillman, que poderiam ser empregados como antioxidante. Entretanto, foi também foco da nossa pesquisa explorar a síntese de novos composto organocalcogênios com propriedades fluorescentes e seu estudo fotofísico
Title in English
Synthesis of Selenium Amino Acid Derivatives and Preliminary Study of its Antioxidant Activity
Keywords in English
Fluorescent probes
Morita-Baylis-Hillman
Organochalcogen
Photophysical study
Abstract in English
Glutathione peroxidases (GPx) are enzymes present in the human body, and many of them are responsible for protecting cells against reactive oxygen species (ROS), which can be detected by fluorescent probes. Selenium or tellurium atoms can be present in these probes and are susceptible to oxidative processes, which can lead to photoinduced electron transfer mechanism (PET). These mechanisms can promote an on/off fluorescence system, thus, selenium amino acids derivatives and fluorescent probes containing chalcogens can be used both in the elimination of reactive oxygen species and their detection. Herein, we proposed the synthesis of selenium amino acids derivatives, vía Morita-Baylis-Hillman reaction, and the products were pointed out as potential antioxidants. In addition, it was also the focus of our research exploring the synthesis of new organochalcogen compounds with fluorescent properties and their photophysical study.
 
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Publishing Date
2017-11-24
 
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