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Master's Dissertation
DOI
10.11606/D.5.2010.tde-10092010-175641
Document
Author
Full name
Thaís Prota Hussein Pincelli
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Nico, Marcello Menta Simonsen (President)
Rivitti, Evandro Ararigboia
Sobrado Junior, Carlos Walter
Title in Portuguese
Manifestações orais da doença inflamatória intestinal: estudo clínico-patológico retrospectivo
Keywords in Portuguese
Doença de Crohn
Doença inflamatória intestinal
Estomatite aftosa
Manifestações bucais
Pênfigo
Pioestomatite vegetante
Retocolite ulcerativa
Abstract in Portuguese
O termo doença inflamatória intestinal engloba duas doenças inflamatórias crônicas, imunologicamente mediadas, envolvendo o trato gastrointestinal: a doença de Crohn e a retocolite ulcerativa. Os sintomas intestinais são predominantes, porém, durante o curso da doença, podem ocorrer manifestações extraintestinais, incluindo o envolvimento da cavidade oral. O envolvimento oral na doença inflamatória intestinal pode se dar por diferentes tipos de lesões, sendo o tipo mais comum a afta. Lesões menos frequentes incluem, entre outras, a pioestomatite vegetante e as lesões granulomatosas da doença de Crohn. Apresentamos dez casos de doentes com manifestações orais de doença inflamatória intestinal, sendo que, em alguns desses casos, essas foram essenciais para o diagnóstico definitivo da doença, além de revisão detalhada da literatura. O envolvimento da cavidade oral pode ser prévio ou simultâneo aos sintomas gastrointestinais. Porém, na maior parte dos casos, a doença inflamatória intestinal precede o início das lesões orais em meses ou anos. Em muitos doentes, a sintomatologia intestinal pode ser mínima ou mesmo ausente, o que justifica exame minucioso do trato gastrointestinal em todos os doentes com lesões orais suspeitas, mesmo na ausência de sintomas evidentes. Geralmente, o curso clínico das lesões orais é paralelo à atividade da doença inflamatória intestinal, por isso as manifestações orais são consideradas bons marcadores cutâneos da doença
Title in English
Oral manifestations of inflammatory bowel disease: retrospective clinical-pathologic study
Keywords in English
Aphtous stomatitis
Crohn disease
Inflammatory bowel disease
Oral manifestations
Pemphigus
Pyostomatitis vegetans
Ulcerative colitis
Abstract in English
Inflammatory bowel disease comprises two chronic, tissue-destructive, clinical entities: Crohns disease and ulcerative colitis, both immunologically based. Bowel symptoms are predominant, but extra-intestinal complications may occur, including involvement of the oral cavity. Oral involvement during Inflammatory bowel disease includes several types of lesions: the most common are aphthae; uncommon lesions include, among others, pyostomatitis vegetans and granulomatous lesions of Crohns disease. Starting with a presentation of ten patients with oral manifestations, which were crucial for the final diagnosis of inflammatory bowel disease, a review on the subject is presented. Oral involvement in inflammatory bowel disease may be previous or simultaneous to the gastrointestinal symptoms. However, in the majority of cases, bowel disease precedes the onset of oral lesions by months or years. In many patients, the intestinal symptoms may be minimal and can go undetected; thus, most authors believe that the bowel must be thoroughly examined in all patients with suspected inflammatory bowel disease even in the absence of specific symptoms. Usually, the clinical course of oral lesions is parallel to the activity of inflammatory bowel disease; therefore, oral manifestations are a good cutaneous marker of inflammatory bowel disease
 
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Publishing Date
2010-09-13
 
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