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Master's Dissertation
DOI
10.11606/D.5.2013.tde-14082013-161717
Document
Author
Full name
Carlos Augusto Fernandes Tavares
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Lerario, Antonio Carlos (President)
Dib, Sérgio Atala
Nery, Márcia
Title in Portuguese
Frequência da doença arterial coronariara (DAC) e características das placas ateroscleróticas avaliadas pela angiotomografia computadorizada multislice em pacientes diabéticos tipo 2 assintomáticos relacionado ao controle glicêmi
Keywords in Portuguese
Aterosclerose/diagnóstico
Diabetes mellitus tipo 2
Doença da artéria coronariana
Hemoglobina A glicosilada
Placa aterosclerótica/classificação
Tomografia computadorizada por raios X/métodos
Abstract in Portuguese
O número de pacientes com diagnóstico de diabetes aumenta a cada dia. Infarto agudo do miocárdio (IAM) e acidente vascular cerebral (AVC) constituem as principais causas de óbito neste grupo. Ruptura da placa aterosclerótica coronariana é o mecanismo fisiopatológico para (IAM) em 2 a cada 3 casos e as características destas placas mais vulneráveis e propensas a ruptura como:remodelamento positivo do segmento vascular afetado e placa não calcificada com baixa atenuação podem ser avaliadas pela Angiotomografia. Objetivo: Avaliar a frequência de doença arterial coronariana e as principais características de vulnerabilidade dessas placas ateroscleróticas em diabéticos assintomáticos considerando o grau de controle glicêmico através da Angiotomografia Computadorizada Multislice. Desenho do estudo e Métodos: 90 pacientes diabéticos tipo 2 assintomáticos, avaliados,entre junho de 2011 a setembro de 2012, entre 40 e 65 anos de idade, tempo de duração do diabetes inferior a 10 anos, submetidos a avaliação clínica, laboratorial e Angiotomografia Computadorizada de artérias coronárias com 320 colunas de detectores. Resultados: Dos 90 pacientes, 42,2% (n=38) apresentaram doença arterial coronariana a Angiotomo sendo n=11 no grupo A1c < 7% e n=27 no grupo A1c >=7% com diferença estatística (p=0,0006). 14 indivíduos apresentaram doença arterial coronariana significativa (obstrução do lúmen superior a 50%), n=3 no grupo A1c<7% e n=11 no A1c>=7% (p=0,02). O tipo de placa não calcificada predominou no grupo A1c>=7% (p=0,005) e 29% dos diabéticos com doença coronária apresentaram lesões ateroscleróticas classificadas como mais vulneráveis que predominaram no grupo A1c>=7% (p=0,04). Conclusão: O paciente diabético assintomático apresenta além de elevada frequência de doença arterial coronariana possui grande número de placas classificadas como vulneráveis pela Angiotomo e portanto predispostas a ruptura e evento coronariano agudo, principalmente no grupo A1c > =7%
Title in English
Frequency of coronary artery disease (cad) and atherosclerotic plaque characteristics assessed by multislice computed angiotomography in asymptomatic type 2 diabetic patients related to glycemic control
Keywords in English
Atherosclerosis/diagnosis
Coronary artery disease
Diabetes mellitus type 2
Hemoglobin A glycosylated
Plaque atherosclerotic/classification
Tomography X-ray computed/methods
Abstract in English
The number of diabetic patients increase every day. Acute myocardial infarction (AMI) and Stroke are the leading causes of death in this group. Coronary atherosclerotic plaque rupture is the pathophysiologic mechanism for (AMI) in 2 every 3 cases and the characteristics of these plaques more vulnerable and prone to rupture as positive remodeling of the vascular segment affected and non-calcified plaque with low attenuation can be evaluated by Angiotomography. Objective: To evaluate the frequency of coronary artery disease and the main characteristics of these vulnerable atherosclerotic plaques in asymptomatic diabetic considering the degree of glycemic control by Multislice Computed Angiotomography. Study Design and Methods: 90 asymptomatic type 2 diabetic patients, evaluated between June 2011 and September 2012, between 40 and 65 years of age, duration of diabetes less than 10 years, underwent clinical, laboratory and Angiotomography Computed coronary arteries with 320 columns of detectors. Results: Of 90 patients, 42.2% (n = 38) had coronary artery disease being the Angiotomo n = 11 in group A1c <7% and n = 27 in group A1c> = 7% with statistical difference (p = 0.0006 ). 14 individuals showed significant coronary artery disease (obstruction of the lumen than 50%), n = 3 in the A1c <7% and n = 11 in A1c> = 7% (p = 0.02). The type of noncalcified plaque predominated in A1c> = 7% (p = 0.005) and 29% of diabetics with coronary disease showed atherosclerotic lesions classified as most vulnerable group that predominated in A1c> = 7% (p = 0.04) . Conclusion: Diabetic patients asymptomatic features besides high frequency of coronary artery disease has a large number of plaques classified as vulnerable by Angiotomo and therefore prone to rupture and acute coronary event, especially in the group A1c> = 7%
 
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Publishing Date
2013-08-15
 
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