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Doctoral Thesis
DOI
10.11606/T.5.2010.tde-23032011-180416
Document
Author
Full name
Maysa Vieira de Sousa
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Silva, Maria Elizabeth Rossi da (President)
Castro, Claudio Campi de
Giannella, Maria Lucia Cardillo Correa
Simões, Herbert Gustavo
Villares, Sandra Mara Ferreira
Title in Portuguese
Suplementação com carboidratos durante treinamento intensivo aumenta as concentrações de lipídios intramiocelulares e reduz os marcadores de lesão tecidual em corredores competitivos: interação hormonal e metabólica
Keywords in Portuguese
Carboidratos
Desempenho atlético
DNA
Espectroscopia de ressonância magnética
Exercício
Hormônio
Insulina
L-lactato desidrogenase
Testosterona
Abstract in Portuguese
O presente estudo objetivou avaliar os efeitos de um microciclo de treinamento intensivo (8 dias), associado ou não à suplementação com carboidratos (CHO), sobre parâmetros metabólicos, hormonais, marcadores de lesão tecidual e estoques de lipídios intramiocelulares em corredores de longa distância. Os efeitos cumulativos desse período de treinamento intensivo e da suplementação com CHO também foram analisados sobre uma sessão de exercício intermitente de alta intensidade e performance atlética (9º dia). Participaram do estudo 24 corredores de longa distância do sexo masculino com 28,0±1,3 anos de idade. Os corredores foram distribuídos em dois grupos (grupo CHO ou grupo controle - CON). No grupo CHO, após treinamento intensivo, foram aumentadas as concentrações dos lipídios intramiocelulares (+0,0061±0,0022 e +0,0008±0,0043 vs. CON: -0,0091±0,0053 e -0,0224±0,0151; dos músculos tibial anterior e sóleo, respectivamente), da testosterona total (694,0±54,6 ng/dL vs. CON: 610,8±47,9 ng/dL) e de sua fração livre (552,7±49,2 pmol/L vs. CON: 395,7±36,6 pmol/L). No 9º dia o protocolo consistiu em uma sessão de 10 séries de 800m (100%Vm3km), com pausa de 1min 30s entre as séries. Antes e após a sessão os atletas realizaram teste máximo de 1.000m. A queda no desempenho do 2º teste de 1.000m foi menor no grupo CHO (5,3±1,0%) vs. 10,7±1,3% no CON. As concentrações de glicose, lactato, epinefrina, cortisol e GH aumentaram após as 10x800m em ambos os grupos. No entanto, essa resposta foi atenuada no grupo CHO para cortisol (22,4±0,9 pmol/L vs. CON: 27,6±1,4 pmol/L) e GH (21,8±5,6 ng/mL vs. CON: 36,7±5,0 ng/mL). Ainda após as 10x800m, as concentrações de LDH e DNA livre foram menores no grupo CHO (509,2±23,1 U/L e 48.240,3±5.431,8 alelos/mL) quando comparadas às do grupo CON (643,3±32,9 U/L e 73.751,8±11.546,6 alelos/ mL, respectivamente). Durante o período de recuperação, a diminuição do cortisol, associada às maiores glicemias e insulinemias no grupo CHO, pode ter resultado em efeito anabólico e atenuação da resposta inflamatória. Conclui-se que a suplementação com CHO atenuou a supressão do eixo hipotalâmico-pituitáriogonadal, além de promover melhora do desempenho atlético, aumento dos estoques de lipídios intramiocelulares e menores respostas catabólicas e dos marcadores de dano tecidual
Title in English
Carbohydrate supplementation during training intensive increases the concentrations of lipids and intramyocellular reduces markers tissue injury in competitive runners: interaction hormonal and metabolic
Keywords in English
Athletic performance
Carbohydrate
DNA
Hormone
Insulin
Lactate dehydrogenase
Magnetic resonance spectroscopy
Testosterone
Abstract in English
This study aimed to evaluate the effects of intensive microcycle training (8days), with and without CHO supplementation, on the metabolic and hormonal responses of long distance runners. Markers for tissue damage and intramyocellular lipid stores were also investigated, along with the cumulative effects of this kind of CHO supplementation on a further session of high intensity intermittent running and athletic performance (day9). The study included 24 male long distance runners with a mean age of 28.0±1.3 years. The runners were divided into two groups (CHO (supplementation) and CON (control)). In the CHO group, the intramyocellular lipids (+0.0061 ± 0.0022 + 0.0008 ± 0.0043 and vs. CON: -0.0091 ± 0.0053 and -0.0224 ± 0.0151; for the tibialis anterior and soleus muscles, respectively) total testosterone (694.0± 54.6 ng/dL vs CON: 610.8±47.9 ng/dL) and its free fraction (552.7±49.2 pmol/L vs CON: 395.7±36.6 pmol/L) were increased after intensive training. On the 9th day all participants ran 10X800m at 100% Vm3km intensity. An all-out 1000m run was performed before and after the 10X800m session and it was noted that the performance decrease for the second 1000m was lower for the CHO-group (5.3±1.0% vs. CON: 10.6±1.3%). Glucose, lactate, epinephrine, cortisol and GH concentrations increased after 10x800m in both groups, but an attenuated response was noted for the CHO group for cortisol (22.4±0.9 pmol/L vs. CON: 27.6±1.4 pmol/L) and GH (21.8±5.6 ng/mL vs. CON: 36.7± 5.0 ng/mL). Moreover, the LDH and free plasma DNA concentrations were lower in the CHO group (509,2±23,1 U/L e 48.240,3±5.431,8 Allels/mL) compared to the CON group ((643,3±32,9 U/L e 73.751,8±11.546,6 Allels / mL, respectively) after the 10X800m run. During the recovery period, the observed lower cortisol response in the CHO group as well as to the higher glucose and insulin concentrations may have resulted in better anabolic effects and attenuation of inflammantion response. This may be linked to. In conclusion CHO supplementation attenuates the suppression of the hypothalamic-pituitary-gonodal axis, and result in better physical performance, higher levels of intramyocellular lipid stores, and lower catabolic responses and levels of markers for tissue damage
 
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Publishing Date
2011-03-25
 
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