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Doctoral Thesis
DOI
10.11606/T.5.2007.tde-11092007-114540
Document
Author
Full name
Alexandre Fogaça Cristante
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Barros Filho, Tarcisio Eloy Pessoa de (President)
Avanzi, Osmar
Machado, Itibagi Rocha
Mattar Junior, Rames
Puertas, Eduardo Barros
Title in Portuguese
Emprego das células progenitoras no tratamento da lesão medular crônica em humanos: análise do potencial evocado somato-sensitivo em 39 pacientes
Keywords in Portuguese
Células-tronco
Humanos
Paralisia
Sistema nervoso central/lesões
Traumatismos da medula espinal
Abstract in Portuguese
O objetivo do presente trabalho foi avaliar o efeito da infusão de células progenitoras indiferenciadas autógenas no tratamento de pacientes com lesão medular crônica. Foram selecionados trinta e nove pacientes com diagnóstico de lesão medular completa cervical e torácica há pelo menos dois anos. Os pacientes foram submetidos à mobilização e coleta das células progenitoras em sangue periférico. O concentrado de células progenitoras foi criopreservado e reinfundido por arteriografia no paciente doador caracterizando o momento zero do experimento. Estes pacientes foram então avaliados por dois anos e meio, sendo submetidos a exames de potencial evocado somato-sensitivo para avaliar a recuperação neurológica após a infusão de células indiferenciadas. Vinte e seis pacientes (66,7%) apresentaram positivação e/ou melhora do tempo de latência do exame de potencial evocado, ou seja, apresentaram resposta cortical aos estímulos periféricos. Assim, após dois anos e meio de seguimento, o protocolo descrito mostrou-se seguro e levou a positivação do exame de potencial evocado somato-sensitivo em pacientes com lesão medular completa.
Title in English
Use of stem cells in the treatment of chronic spinal cord injury in humans: evaluation of somatosensitive evoked potential in 39 patients
Keywords in English
Central nervous system/injuries
Humans
Paralysis
Spinal cord injuries
Stem cells
Abstract in English
The objective of this study was to evaluate the effect of autogenous undifferentiated progenitor cell infusion in the treatment of patients with chronic spinal cord injury. Thirty-nine patients were selected among those diagnosed with complete cervical and thoracic spinal cord injury for at least two years. Patients underwent peripheral blood stem cell mobilization and collection. The progenitor cell concentrate was cryopreserved and reinfused through arteriography into the donor patient, characterizing the time zero of the experiment. These patients were then evaluated during two and a half years, being submitted to examinations with somatosensitive evoked potential to evaluate neurological recovery after undifferentiated cell infusion. Twenty-six patients (66,7%) were positive for evoked potential, that is, they presented cortical response to peripheral stimuli. In two and a half year, this protocol was safe for the patients and cause positive answers for evoked potentials in patients with complete spinal cord lesion.
 
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alexandrefcristante.pdf (826.44 Kbytes)
Publishing Date
2007-09-17
 
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