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Master's Dissertation
DOI
10.11606/D.5.2008.tde-29012009-131837
Document
Author
Full name
Roberto Minoru Hita
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Oliveira, Reginaldo Perilo (President)
Cristante, Alexandre Fogaça
Rodrigues, Nilson Rodnei
Title in Portuguese
Análise funcional e histológica da ação da neurotropina-4 sobre a lesão medular em ratos
Keywords in Portuguese
Fatores de crescimento neural
Ratos Wistar
Traumatismo da medula espinal
Abstract in Portuguese
As pesquisas em lesão medular tiveram um avanço significativo nas últimas duas décadas. Várias substâncias têm sido testadas, dentre elas, os fatores neurotróficos que são proteínas que auxiliam na maturação e desenvolvimento do sistema nervoso. O objetivo deste estudo foi conduzir testes que propiciem a análise dos efeitos da recuperação funcional locomotora e regeneração axonal em ratos submetidos a testes experimentais com a utilização da substância neurotropina-4. O estudo consistiu de 30 ratos adultos jovens, da raça Wistar, que foram submetidos à lesão medular ao nível de TX, provocado por um aparelho denominado NYU impactor. Os ratos foram divididos em dois grupos de 15 ratos cada, denominados de grupo controle e grupo tratamento, que receberam aplicação de água destilada e 1g de neurotropina-4, respectivamente. Estes foram avaliados funcionalmente pela escala BBB e submetidos à análise histológica. Concluiu-se que a neurotropina-4 promove a recuperação locomotora funcional e diminui os efeitos secundários da lesão medular, comparativamente ao grupo controle
Title in English
Functional and histological analysis of the neurotrophin-4 on medullar injury of rats
Keywords in English
Nerve growth factors
Rats Wistar
Spinal cord trauma
Abstract in English
Research into spinal cord injury has advanced significantly over the past two decades. Many substances have been tested, including the neurotrophics factors, which are proteins that aid in the maturation and development of the nervous system. The objective of this study was to conduct tests that provide the analysis of the effects of the locomotor functional recovery and axonal regeneration in rats subjected to experimental tests with the use of the substance neurotrophin-4. The study consisted of thirty young adult rats, Wistar race, which received TX level of spinal cord injury through a device called NYU impactor. The rats were divided into two groups of fifteen rats each, called the control group and treatment group, which received application of distilled water and 1 g Neurotrophin-4, respectively. They were evaluated functionally by the BBB scale and submitted to the histological analysis. It was concluded that the Nt-4 promotes the recuperation of the locomotor function and reduces the side effects of spinal cord injury, compared to the control group
 
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RobertoMinoruHita.pdf (2.26 Mbytes)
Publishing Date
2009-02-13
 
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