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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-27012006-091929
Document
Author
Full name
Hilton Kuperman
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Damiani, Durval (President)
Dichtchekenian, Vaê
Guerra Júnior, Gil
Koch, Vera Hermina Kalika
Setian, Nuvarte
Title in Portuguese
"Estudo duplo-cego comparativo entre prednisona e dexametasona na avaliação da reserva adrenal em crianças e adolescentes com leucemia linfocítica aguda"
Keywords in Portuguese
ADOLESCENTE
CORTICOTROPINA
CRIANÇA
DEXAMETASONA
GLÂNDULAS SUPRA-RENAIS
GLUCORTICÓIDES
LEUCEMIA LINFOCÍTICA AGUDA
PREDNISONA
Abstract in Portuguese
Para avaliar a reserva adrenal após o uso de glicocorticóide na fase de indução de remissão em pacientes com Leucemia Linfocítica Aguda, estudo duplo-cego foi realizado em 29 crianças e adolescentes de 1,7 a 15,9 anos (média:6,8 anos], que receberam por escolha aleatória, Prednisona na dose de 40 mg/m²/dia ou Dexametasona, 6 mg/m²/dia, via oral, por um mês. Testes do ACTH em baixa dose (1,0 µg/m² EV) foram realizados antes e a cada 7 dias por 8 semanas para avaliar pico de cortisol após o estímulo. Não houve diferença significativa entre as médias dos picos de cortisol nos testes realizados em cada grupo e entre os dois grupos, mostrando reserva adrenal adequada. Não houve correlação entre os picos de cortisol nos dois grupos e a presença de infecção
Title in English
Evaluation of adrenal reserve in children and adolescents with acute lymphocytic leukemia through a double-blind comparison between Prednisone and Dexamethasone
Keywords in English
ADOLESCENT
ADRENAL GLANDS
CHILD
CORTICOTROPIN
DEXAMETHASONE
LEUKEMIA LYMPHOCYTIC ACUTE
PREDNISONE
Abstract in English
In order to evaluate adrenal reserve after adminstration of glucocorticoid during induction phase in patients with Acute LymphociticLeukemia, a double-blind study was performed in 29 children and adolescents 1,7 to 15.9 years old (mean: 6.8 years old), who randomly were chosen to receive either Prednisone, 40 mg/m²/day or Dexamethasone, 6 mg/m²/day, PO, for one month. Low-dose ACTH tests (1.0 µg/m² IV), were performed before and every 7 days after glucocorticoid for 8 weeks. There were no significant differences of cortisol mean peak levels in the tests of each group and in both group, suggesting adequate adrenal reserve. There was no correlation of cortisol mean peak levels in both groups and the presence of infection
 
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HiltonKuperman.pdf (2.29 Mbytes)
Publishing Date
2006-02-14
 
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