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Thèse de Doctorat
DOI
10.11606/T.5.2005.tde-27092005-160409
Document
Auteur
Nom complet
Lúcia Maria de Arruda Campos
Adresse Mail
Unité de l'USP
Domain de Connaissance
Date de Soutenance
Editeur
São Paulo, 2005
Directeur
Jury
Kiss, Maria Helena Bittencourt (Président)
Costallat, Lilian Tereza Lavras
Pereira, Rosa Maria Rodrigues
Sampaio, Magda Maria Sales Carneiro
Sato, Emilia Inoue
Titre en portugais
Anticorpos antinucleossomo em pacientes com lúpus eritematoso sistêmico juvenil.
Mots-clés en portugais
Adolescente
Auto-anticorpos
Criança
Lúpus eritematoso sistêmico
Nucleossomos/imunologia
Resumé en portugais
Este estudo teve por objetivos avaliar a positividade do anticorpo antinucleossomo (anti-Ncs) no LES juvenil, sua associação com manifestações e atividade da doença e compará-lo ao anticorpo anti-DNA. A pesquisa dos anticorpos anti-Ncs e anti-DNA foi realizada em 74 pacientes com LESJ e 64 controles. Os anti-Ncs e anti-DNA demonstraram sensibilidade de 52.7% e 54% e especificidade de 98.4% e 95.3%, respectivamente. Nesta população, foi observada discordância de 25.7% entre os anticorpos, sugerindo que os mesmos sejam complementares em termos diagnósticos. Houve associação entre anti-Ncs e rash malar, anemia hemolítica, FAN, anti-DNA e diminuição de C3 e C4, mas não com o quadro renal. Os títulos do anti-Ncs correlacionaram-se à atividade da doença (SLEDAI), demonstrando seu valor prognóstico.
Titre en anglais
Antinucleosome antibodies in patients with juvenile systemic lupus erythematosus.
Mots-clés en anglais
Adolescent
Autoantibodies
Child
Lupus erythematosus systemic
Nucleosomes/immunology
Resumé en anglais
The aims of this study were to evaluate the positivity of antinucleosome antibodies (Anti-Ncs) in SLE children, their association to disease manifestations and activity, and to compare them to anti-DNA antibodies. Anti-Ncs and anti-DNA were tested on 74 JSLE patients and 64 controls. Anti-Ncs and anti-DNA showed sensitivity of 52.7% and 54% and specificity of 98.4% and 95.3%, respectively. The discordance of 25.7% between the antibodies found on the studied population suggests that they may have a complementary diagnosis role. Anti-Ncs were associated to malar rash, hemolytic anemia, ANA, anti-DNA and low complement levels, but no association was observed to renal manifestations. The correlation observed between anti-Ncs titers and disease activity (SLEDAI) demonstrated its prognostic value.
 
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Date de Publication
2005-10-07
 
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