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Doctoral Thesis
DOI
10.11606/T.5.2006.tde-12042006-162203
Document
Author
Full name
Jeanne da Rosa Oiticica Ramalho
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Bento, Ricardo Ferreira (President)
Brito Neto, Rubens Vuono de
Jorge Junior, Jose Jarjura
Portinho, Fernando Sérgio de Melo
Sanchez, Tanit Ganz
Title in Portuguese
"Cicatrização de perfurações subagudas de membrana timpânica de chinchilas tratadas com fator de crescimento epitelial e pentoxifilina"
Keywords in Portuguese
Chinchila
Cicatrização de feridas
Fator de crescimento epidérmico
Membrana timpânica
Miringoplastia
Orelha média
Pentoxifilina
Perfuração de membrana timpânica
Timpanoplastia
Abstract in Portuguese
O efeito do fator de crescimento epitelial e da pentoxifilina, isolados ou em associação, foi avaliado em perfurações subagudas de membranas timpânicas de chinchilas, comparando-se ao grupo controle. O fator de crescimento epitelial auxiliou o processo de cicatrização de perfurações subagudas de membranas timpânicas, o que não se observou com a pentoxifilina. O percentual de cicatrização das perfurações foi de 30,3%, 3,6%, 16,5% e 8,7% nos grupos fator de crescimento epitelial, pentoxifilina, fator de crescimento epitelial com pentoxifilina e controle, respectivamente
Title in English
Healing of subacute tympanic membrane perforations in chinchillas treated with epidermal growth factor and pentoxifylline
Keywords in English
Chinchilla
Ear middle
Epidermal growth factor
Myringoplasty
Pentoxifylline
Tympanic membrane
Tympanic membrane perforation
Tympanoplasty
Wound healing
Abstract in English
The effect of epidermal growth factor and pentoxifylline, in combination or alone, was evaluated in chinchillas with subacute tympanic membrane perforations, and compared with a control group. Epidermal growth factor helped in the healing of subacute tympanic membrane perforations, but the same was not observed for pentoxifylline. The healing rate of perforations was 30.3%, 3.6%, 16.5% and 8.7% for the following groups: epidermal growth factor, pentoxifylline, epidermal growth factor with pentoxifylline and untreated controls, respectively
 
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Publishing Date
2006-04-13
 
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