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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-20102005-113139
Document
Author
Full name
Mônica Aidar Menon Miyake
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Butugan, Ossamu (President)
Granato, Lidio
Mello Junior, João Ferreira de
Miniti, Aroldo
Pereira, Elisabeth Araújo
Title in Portuguese
"Efeitos da infusão de Luffa operculata sobre o epitélio e a atividade mucociliar do palato isolado de rã"
Keywords in Portuguese
DEPURAÇÃO MUCOCILIAR
JUNÇÕES ÍNTIMAS/efeitos de drogas
LUFFA OPERCULATA
MEDICINA HERBÁRIA
MUCOSA NASAL/efeitos de drogas
PLANTAS MEDICINAIS/toxicidade
PLANTAS MEDICINAIS/uso terapêutico
RANA CATESBEIANA
RINITE/terapia
SINUSITE/terapia
Abstract in Portuguese
Luffa operculata é uma planta medicinal popularmente usada para tratamento de rinites e rinossinusites. A infusão de seu fruto seco é usada no nariz, liberando secreção mucosa profusa, mas pode causar irritação, epistaxe ou anosmia. Avaliamos os efeitos de diferentes concentrações da infusão do fruto seco da Luffa operculata na velocidade de transporte mucociliar (VTM), freqüência de batimento ciliar (FBC), diferença de potencial transepitelial (DPT) e morfologia do epitélio (microscopia de luz e eletrônica de transmissão), no modelo do palato isolado de rã. Os resultados apontam para dano epitelial dose-dependente no epitélio mucociliar, sugerindo que ela seja potencialmente nociva à mucosa nasal humana
Title in English
Effects of Luffa operculata infusion on the epithelium and the mucociliary activity of the isolated frog palate
Keywords in English
LUFFA OPERCULATA
MEDECINE HERBAL
MUCOCILIARY CLEARANCE
NASAL MUCOSA/drug effects
PLANTS MEDICINAL
PLANTS MEDICINAL/toxicity
RANA CATESBEIANA
RHINITIS/therapy
SINUSITIS/therapy
TIGHT JUNCTIONS/drug effects
Abstract in English
Luffa operculata is a medicinal plant popularly used for treatment of rhinitis and rhinosinusitis. Its dry fruit infusion is used into the nose, delivering profuse mucous secretion, but may cause nasal mucosa irritation, epistaxis or anosmia. We evaluated the effects of different concentrations of Luffa operculata dry fruit infusion on mucociliary transport velocity (MTV), ciliary beat frequency (CBF), transepithelial potential difference (TPD) and epithelial morphology (light and electron transmission microscopy) of the isolated frog palate preparation. Results pointed to dose-dependent epithelial damage on mucociliary epithelium, suggesting that it is potentially noxious to the human nasal mucosa
 
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anexo5.pdf (167.60 Kbytes)
monicamiyake.pdf (1.76 Mbytes)
Publishing Date
2005-10-20
 
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