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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-06102014-094007
Document
Author
Full name
Ana Paula Torres Schor
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Carvalho, Filomena Marino (President)
Barbosa, Edison Mantovani
Bernardi, Fabiola Del Carlo
Kemp, Cláudio
Zerbini, Maria Claudia Nogueira
Title in Portuguese
Associação da proteína S100P e do receptor de estrogênio com o potencial evolutivo de lesões proliferativas epiteliais mamárias em pacientes com calcificações radiológicas
Keywords in Portuguese
Biópsia por agulha/métodos
Doenças mamárias/patologia
Imunohistoquímica/métodos
Abstract in Portuguese
As doenças benignas da mama respondem pela maior parte dos diagnósticos em patologia mamária, por esse motivo têm se tornado um problema crescente na prática clínica pela limitação diagnóstica atual em identificar o subgrupo de lesões com maior potencial de risco par neoplasia invasora. O estudo das lesões proliferativas com marcadores prognósticos do câncer de mama mostrou que o estrogênio exerce papel importante na transformação dessas lesões, através do seu receptor nuclear, induzindo a transcrição de genes, mas também pelo receptor de membrana citoplasmática, estimulando a proliferação celular através da ativação das proteína-quinases ativadas por mitógenos. Trabalhos experimentais com culturas de células de diferentes linhagens, incluindo células mamárias, identificaram a proteína S100P, uma proteína ligante de cálcio, como participante da transformação neoplásica maligna e diferenciação celular. No presente trabalho, estudamos a expressão da S100P, do receptor de estrogênio e avaliamos a proliferação celular de 155 pacientes submetidas à biópsia mamária por agulha grossa assistida a vácuo, guiada por estereotaxia, população que corresponde à rotina diagnóstica em patologia mamária. Comprovamos a associação do receptor de estrogênio com as lesões pré-malígnas, classificadas segundo seu potencial de risco para neoplasia invasora, principalmente em mulheres abaixo dos 50 anos. Demonstramos haver forte associação entre a S100P e o receptor de estrogênio na distinção do potencial de risco das lesões histológicas, confirmando o papel importante da S100P no processo de transformação maligna. Observamos que a ausência da proteína torna praticamente nula a possibilidade de progressão tumoral, e mais ainda que sua ação depende também do receptor de estrogênio
Title in English
S100P and estrogen receptor associated with evolutive potential of epithelial proliferative breast lesions in patients with radiologic calcifications
Keywords in English
Biopsy needle/methods
Breast diseases/pathology
Immunohistochemistry/methods
Abstract in English
The benign breast diseases represent the major diagnose in breast pathology, so they have became an increasing problem concerning the clinical practice for limited capability diagnosis to identify a subgroup in this category with greater risk to evolve to invasive breast cancer. Studies with proliferative breast lesions and prognostic markers of breast cancer have shown that estrogen plays an important roll in malignant transforming process through its nuclear receptor which activates the transcriptional process. Moreover, the surface estrogen receptor stimulates the cell proliferation as a result of activation of mitogen-activated protein-kinases cascade. In vitro experiments with differents cell lines, including breast cell ones, have identified a protein, called S100P, a calcium-binding protein, as participating of the malignant transforming process and cell differentiation. In the present work, we studied the immunoexpression expression of S100P, estrogen receptor and evaluated the cell proliferation of 155 patients submitted to vacuum assisted core biopsy with stereotactic guidance of breast, a population that corresponds to the routine diagnose in breast pathology. We have proved the association between estrogen receptor and premalignant lesions, stratified by the relative risk for developing invasive breast cancer, mainly among women under the 50 years. We also have demonstrated a strong association of S100P and estrogen receptor concerning the distinctive relative risk of breast histologic lesions; bring up the important contribution of S100P in the carcinogenetic process. Meanwhile, the presence of S100P rises up the transforming possibility. We finally have found that the action of S100P depends on the estrogen receptor status
 
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Publishing Date
2014-10-07
 
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