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Doctoral Thesis
DOI
10.11606/T.5.2006.tde-17042006-151846
Document
Author
Full name
Sheila Aparecida Coelho Siqueira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Alves, Venancio Avancini Ferreira (President)
Brito, Thales de
Paes, Roberto Antônio Pinto
Pereira, Juliana
Zerbini, Maria Claudia Nogueira
Title in Portuguese
"Contribuição da imuno-histoquímica para a classificação dos linfomas de pequenas células B"
Keywords in Portuguese
Classificação
Imunohistoquímica
Linfoma de pequenas células
Prognóstico
Abstract in Portuguese
Nós avaliamos a utilidade de um painel de anticorpos constituído por CD5, CD10, CD23, CD43, bcl-2 e ciclina D1 na classificação de 134 linfomas de pequenas células B. O CD10, positivo nos linfomas foliculares, o CD23, positivo nos linfomas linfocíticos/LLC, e a ciclina D1, expressa nos linfoma do manto, foram os que mais contribuíram na diferenciação destes linfomas, firmando o diagnóstico em 88,1% dos casos. A ausência de aspecto nodular e de células dendríticas, e a presença de centros de proliferação diferencia o linfoma linfocítico/LLC dos outros tipos. A expressão de proteína p53 e de antígeno Ki-67 > 20% foi associada com tempo de sobrevida menor, principalmente no linfoma do manto
Title in English
Contribution of immunohistochemistry to small B cell lymphomas classification
Keywords in English
Classification
Immunohistochemistry
Lymphoma small-cell
Prognosis
Abstract in English
We evaluated the usefulness of a panel of antibodies comprising CD5, CD10, CD23, CD43, bcl-2 and cyclin D1 in the classification of 134 small B-cell lymphomas. CD10, positive in follicular lymphomas, CD23, positive in lymphocytic lymphoma/CLL and cyclin D1 expressed in mantle cell lymphoma were the ones that contributed the most in the differentiation of these lymphomas, confirming the diagnosis in 88.1% of the cases. The absence of nodular aspect and dendritic cells and the presence of proliferation centers differentiate the lymphocytic lymphoma/CLL from the other types. The expression of p53 protein and Ki-67 > 20% was associated to a shorter survival, especially in mantle cell lymphoma
 
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SheilaAC.pdf (2.74 Mbytes)
Publishing Date
2006-04-19
 
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