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Doctoral Thesis
DOI
10.11606/T.5.2008.tde-25062008-161827
Document
Author
Full name
Sylvia Regina Temer Cursino
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Andrade Junior, Heitor Franco de (President)
Duarte, Maria Irma Seixas
Oréfice, Fernando
Silva, Maria Antonieta Longo Galvão da
Sotto, Mirian Nacagami
Title in Portuguese
Evidências sorológicas e experimentais da resposta autoimune humoral contra a retina em uveites causada por Toxoplasma gondii
Keywords in Portuguese
Arrestina
Formação de anticorpos/imunologia
Modelos animais
Retina/imunologia
Toxoplasma
Uveíte posterior
Vacinas atenuadas
Abstract in Portuguese
A toxoplasmose ocular é atribuída ao parasita, mas a auto-imunidade pode participar do processo. Soros humanos com IgG positiva para T. gondii mostraram níveis altos de IgG anti-retina para diferentes antígenos, se comparados com soros negativos para T. gondii, uveítes de outras origens também tiveram títulos elevados. Hamsters imunizados e/ou infectados não mostraram estes anticorpos sem mimetismo antigênico. A retinocoroidite por Toxoplasma induz resposta humoral auto-imune contra antígenos da retina, provavelmente piorando o efeito direto do agente. Estes anticorpos podem ser usados como marcadores de doença ocular em pacientes soropositivos para toxoplasmose pela triagem de lesão ocular.
Title in English
Experimental and serological evidence of humoral autoimmune response against retina in Toxoplasma gondii uveitis
Keywords in English
Antibody formation/immunology
Arrestin
Models animals
Retina/immunology
Toxoplasma
Uveitis posterior
Vaccines attenuated
Abstract in English
Ocular toxoplasmosis is attributed to the parasite, but autoimmunity could have a role in this process. Human sera, positive of anti-T. gondii IgG, show high levels of anti-retina IgG, measured by several antigens, as compared to T. gondii seronegative samples. Sera from patients with uveitis from other origins also had higher anti-retina abs levels. Challenged and/or immunized hamsters showed low anti-retina abs levels, without antigen mimicry. Toxoplasmic retinochoroiditis presents a humoral anti-retina abs, probably worsening the parasite direct effect. Those antibodies could be used as markers of eye involvement in toxoplasmosis seropositive patients, as a screening for eye examination.
 
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Publishing Date
2008-06-30
 
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