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Master's Dissertation
DOI
10.11606/D.5.2006.tde-14092006-153912
Document
Author
Full name
Ricardo Tedeschi Matos
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2006
Supervisor
Committee
Rodriguez, Tomás Navarro (President)
Chinzon, Decio
Eisig, Jaime Natan
Title in Portuguese
"Avaliação do espaço intercelular dilatado da mucosa esofágica antes e após infunsão de ácido clorídrico: marcador da doença do refluxo gastroesofágico (DRGE)"
Keywords in Portuguese
Ácido clorídrico
Diagnóstico
Epitélio
Espaço intercelular
Marcadores biológicos
Membrana mucosa
Microscopia eletrônica
Refluxo gastroesofágico/patologia
Abstract in Portuguese
O objetivo foi evidenciar a presença do espaço intercelular dilatado do epitélio esofágico após a infusão de ácido clorídrico (HCl) à 0,1N comparando com a infusão de soro fisiológico (SF) em pacientes sem sintomas típicos da DRGE com mucosa esofágica normal e compará-los com os de sintomas típicos e esofagite erosiva. Foram entrevistados e realizaram o exame de endoscopia digestiva alta 60 pacientes destes, 29 foram incluídos no estudo sendo 18 com esôfago normal (9 foram infundidos SF e 9 HCl) e 11 com esofagite erosiva (6 foram infundidos SF e 5 HCl) e foram realizados 4 biópsias da mucosa esofágica (2 antes e 2 depois das infusões). Não foi encontrado diferença estatisticamente significante no espaço intercelular da mucosa esofágica dos pacientes com e sem esofagite erosiva com ácido clorídrico ou soro fisiológico não sendo um marcador da DRGE
Title in English
Evaluation of the extended intercellular space of the esophagic mucous membrane before and after infusion of chloridric acid : marker of disease of gastroesophagic reflux
Keywords in English
Biological markers
Diagnosis
Epithelium
Extracellular space
Gastroesophageal reflux/pathology
Hydrochloric acid
Microscopy electron
Mucous membrane
Abstract in English
The purpose was to prove the presence of extended intercellular space of the esophagic epithelium after chloridric acid infusion (HCI) to 0,1N comparing to the physiologic serum infusion (PS) in patients without typical symptoms of DGER with normal esophagic mucous membrane and compare them to ones with typical symptoms and erosive esophagitis. 60 patients were interviewed and took the high digestive endoscopy; 29 were included in the research, among them 18 with normal esophagus (9 were infused PS, and 9 HCI) and 11 with erosive esophagitis (6 were infused PS and 5 HCI); 4 biopsies of esophagic mucous membrane were made (2 before and 2 after infusions). It was not found any statistically meaningful difference in intercellular space of esophagic mucous membrane in patients with or without erosive esophagitis with chloridric acid or physiologic serum, and thus it is not a DGER
 
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Publishing Date
2006-10-11
 
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