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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-12092005-103213
Document
Author
Full name
Carlos Viana Poyares Jardim
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Souza, Rogério de (President)
Caruso, Pedro
Carvalho, Carlos Roberto Ribeiro de
Demarzo, Sergio Eduardo
Romaldini, Helio
Title in Portuguese
"Avaliação da distensibilidade da artéria pulmonar através da ressonância magnética e sua relação com a resposta ao teste agudo com vasodilatador em pacientes com hipertensão arterial pulmonar"
Keywords in Portuguese
ARTÉRIA PULMONAR/fisiopatologia
CIRCULAÇÃO PULMONAR/fisiologia
FENÔMENOS HEMODINÂMICOS/efeitos de drogas
HIPERTENSÃO PULMONAR
IMAGEM POR RESSONÂNCIA MAGNÉTICA
Abstract in Portuguese
A hipertensão arterial pulmonar idiopática é uma doença que acomete os vasos arteriais pulmonares, determinando o aumento da resistência vascular pulmonar levando à deterioração hemodinâmica. Avaliamos se a distensibilidade da artéria pulmonar avaliada pela ressonância magnética se correlaciona à resposta ao teste agudo com vasodilatador em pacientes com hipertensão pulmonar. Houve diferença significativa de distensibilidade da artéria pulmonar em pacientes respondedores e não-respondedores. Após a análise dos dados por uma curva ROC, a distensibilidade de 10% distinguiu a população de respondedores de não-respondedores com 100% de sensibilidade e 56% de especificidade
Title in English
Pulmonary artery distensibility assessed by magnetic resonance and its relation to acute vasodilator test response in pulmonary arterial hypertension patients
Keywords in English
HEMODYNAMIC PHENOMENA/drug effects
HYPERTENSION PULMONARY
MAGNETIC RESONANCE IMAGING
PULMONARY ARTERY/physiopathology
PULMONARY CIRCULATION/physiology
Abstract in English
Pulmonary arterial hypertension is characterized by an increase in pulmonary vascular resistance, eventually leading to hemodynamic failure. We assessed whether pulmonary artery distensibility (evaluated by magnetic resonance) correlated with acute vasodilator test response. A statistically significant difference was found in terms of pulmonary artery distensibility in responders and non-responders. A ROC curve showed that 10% distensibility could discriminate responders from non-responders with 100%sensitivity and 56% specificity
 
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CarlosJardim.pdf (305.22 Kbytes)
Publishing Date
2005-10-05
 
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