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Doctoral Thesis
DOI
10.11606/T.5.2008.tde-14042008-105330
Document
Author
Full name
Juliana Carvalho Ferreira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Carvalho, Carlos Roberto Ribeiro de (President)
Amato, Marcelo Britto Passos
Deheinzelin, Daniel
Franca, Suelene Aires
Zin, Walter Araújo
Title in Portuguese
Avaliação da mecânica do sistema respiratório através da obtenção de curva PV em pacientes com pneumonia intersticial idiopática
Keywords in Portuguese
Doenças pulmonares intersticiais
Fibrose pulmonar/fisiopatologia
Mecânica respiratória
Sistema respiratório
Abstract in Portuguese
O objetivo desse estudo foi avaliar o comprometimento de pequenas vias aéreas na Fibrose Pulmonar Idiopática (FPI) analisando curvas Pressão- Volume (PV) do sistema respiratório. Coletamos curvas PV de doze pacientes antes da biopsia pulmonar, que confirmou FPI em sete pacientes e Pneumonite de Hipersensibilidade em cinco. Todas as curvas foram ajustadas com modelo sigmóide, V = a + b / (1 + e -(P-c/d)), e exponencial V = A - B . e -k.P (aplicado apenas à parte superior). O modelo exponencial, apesar do bom ajuste à parte superior, não representou a parte inicial da curva, gerando parâmetros sem significado. O modelo sigmóide ajustou bem toda a curva e gerou parâmetros com significado fisiológico, que sugerem a presença de colapso de pequenas vias aéreas na FPI.
Title in English
Evaluation of the mechanics of the respiratory system using PV curves in patients with idiopathic pulmonary fibrosis
Keywords in English
Interstitial lung diseases
Pulmonary fibrosis/physiopathology
Respiratory mechanics
Respiratory system
Abstract in English
The objective of this study was to evaluate small airways compromise in Idiopathic Pulmonary Fibrosis (IPF) using pressure-volume (PV) curves of the respiratory system. We collected PV curves from twelve patients before lung biopsy, which confirmed IPF in seven patients and Hipersensitivity Pneumonia in five. All curves were fitted with a sigmoid model, V = a + b / (1 + e -(P-c/d)), and an exponential model, V = A - B . e -k.P (applied only to the superior part of the curve). The exponential model, despite having a good fit to the superior part of the curve, did not represent the initial part, and yielded parameters with no physiological meaning. The sigmoid model had a good fit to the entire curve and yielded parameters with physiological meaning, suggesting the presence of small airways collapse in IPF.
 
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julianaferreira.pdf (4.90 Mbytes)
Publishing Date
2008-04-23
 
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