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Doctoral Thesis
DOI
10.11606/T.5.2007.tde-19042011-150516
Document
Author
Full name
João Marcos Salge
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Carvalho, Carlos Roberto Ribeiro de (President)
Nery, Luiz Eduardo
Queluz, Thais Helena Abrahão Thomaz
Souza, Rogério de
Tucci, Mauro Roberto
Title in Portuguese
Estudo funcional do acometimento das pequenas vias aéreas nas pneumopatias intersticiais fibrosantes
Keywords in Portuguese
Biópsia
Doenças pulmonares intersticiais
Mecânica respiratória
Resistência das vias respiratórias
Volume de oclusão
Abstract in Portuguese
Apesar de bem estabelecido em termos morfológicos, a repercussão funcional do envolvimento das pequenas vias aéreas nas pneumopatias intersticiais fibrosantes (PIF) permanece controversa. O presente estudo avaliou de maneira invasiva e não-invasiva (espirometria, volume de fechamento, variação da complacência dinâmica com a freqüência respiratória) a função das pequenas vias aéreas em portadores de PIF, comparando com grupo controle e correlacionando com índices morfométricos de biópsias. Os testes funcionais não diferenciaram portadores da doença dos controles quanto ao acomentimento das pequenas via aéreas e não se correlacionaram com os dados morfométricos
Title in English
Physiological study of small airwayfunction in fibrosing interstitial lung disease
Keywords in English
Airway resistance
Biopsy
Closing volume
Interstitial lung disease
Respiratory mechanics
Abstract in English
Although well known involvement of small airway in fibrosing interstitial lung disease based on morfologic issues, its functional consequences remains controversial. We present an invasive and non-invasive physiologic study for small airway function (pulmonary function tests, closing volume and frequency dependence of dynamic compliance) in patients with lung fibrosis. The physiological data were compared with normal controls and correlated with morfometric measurements from biopsies. Specific small airway function data could not show obstructive pattern when compared with normals, and did not correlate with morofmetric data
 
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JoaoMarcosSalge.pdf (1.46 Mbytes)
Publishing Date
2011-04-19
 
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