Estudo do efeito do contraste paramagnético na amplitude e largura dos picos dos metabólitos na espectroscopia com múltiplos volumes de interesse em pacientes com tumores intracranianos

Lima, Eduardo Carneiro

doi:10.11606/T.5.2005.tde-17022006-095136

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Doctoral Thesis

DOI

https://doi.org/10.11606/T.5.2005.tde-17022006-095136

Document

Doctoral Thesis

Author

Lima, Eduardo Carneiro (Catálogo USP)

Full name

Eduardo Carneiro Lima

Institute/School/College

Faculdade de Medicina

Knowledge Area

Radiology

Date of Defense

2005-12-14

Published

São Paulo, 2005

Supervisor

Leite, Claudia da Costa (Catálogo USP)

Committee

Leite, Claudia da Costa (President)
Amaro Júnior, Edson
Miura, Flávio Key
Reed, Umbertina Conti
Rocha, Antonio José da

Title in Portuguese

"Estudo do efeito do contraste paramagnético na amplitude e largura dos picos dos metabólitos na espectroscopia com múltiplos volumes de interesse em pacientes com tumores intracranianos"

Keywords in Portuguese

COLINA
CREATINA
ESPECTROSCOPIA DE RESSONÂNCIA MAGNÉTICA
GADOLÍNIO
GADOLÍNIO DTPA
MEIOS DE CONTRASTE
NEOPLASIAS CEREBRAIS

Abstract in Portuguese

Para avaliar o efeito do gadolínio sobre os metabólitos Colina (CO), Creatina (CRE) e N-acetil-aspartato (NAA) foi realizada espectroscopia por ressonância magnética em 25 pacientes com tumores intracranianos antes e após a injeção venosa do meio de contraste. Foram quantificadas e comparadas as relações CO/CRE, CO/NAA e NAA/CRE bem como a largura a meia altura dos picos dos metabólitos CO, CRE e NAA nos espectros pré e pós-contraste. Verificou-se redução das relações CO/CRE e CO/NAA e da largura a meia altura do pico do NAA nos espectros pós-contraste

Title in English

Analysis of the effect of the paramagnetic contrast in the amplitude and width of the metabolite peaks using multivoxel spectroscopy in patients with intracranial tumors

Keywords in English

BRAIN NEOPLASMS
CHOLINE
CONTRAST MEDIA
CREATINE
GADOLINIUM
GADOLINIUM DTPA
MAGNETIC RESONANCE SPECTROSCOPY

Abstract in English

In order to evaluate the gadolinium effect on the metabolites choline (CHO), creatine (CRE) and N-acetyl-aspartate (NAA) we performed multivoxel spectroscopy in 25 patients with intracranial tumors before and after the injection of the contrast material. The metabolite ratios CHO/CRE, CHO/NAA and NAA/CRE and the peak width at half height of the metabolites were calculated and compared between the pre and post contrast spectra. Measurements showed reduction of the CO/CRE and CO/NAA ratios and of the NAA width after the administration of the contrast material

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Publishing Date

2006-02-24

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