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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-10082005-153351
Document
Author
Full name
Flavia Regina Rotea Mangone
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Federico, Miriam Hatsue Honda (President)
Moreira Filho, Carlos Alberto
Nunes, Fabio Daumas
Silva, Eloiza Helena Tajara da
Younes, Riad Naim
Title in Portuguese
"Determinação do perfil de expressão dos RNAs mensageiros da família das Smads e dos componentes do complexo AP-1 em carcinoma de célula escamosa de cabeça e pescoço"
Keywords in Portuguese
CARCINOMA DE CÉLULAS ESCAMOSAS/fisiopatologia
ENSAIOS DE PROTEÇÃO DE NUCLEASES/métodos
FATOR DE CRESCIMENTO TRANSFORMADOR BETA
FATORES DE TRANSCRIÇÃO
FATORES DE TRANSCRIÇÃO AP 1
NEOPLASIAS DE CABEÇA E PESCOÇO/fisiopatologia
NORTHERN BLOTTING/métodos
RNA MENSAGEIRO
Abstract in Portuguese
A expressão de Smads e de membros da família AP1/ jun-fos podem refletir alterações da via de TGFb, uma via importante para o câncer epidermóide de cabeça e pescoço (HNSCC). Encontramos expressão aumentada dos mRNAs das Smads1-8 em HNSCC em comparação com tecido normal adjacente, por RPA. Além disso, as curvas de sobrevida de Kaplan Meier e a análise multivariada mostraram que a Smad6+ parece ser um fator determinante de bom prognóstico em HNSCC. Quanto a família AP-1, mensurado por Northern blot, somente Fra-1 mostrou-se aumentado no tumor e associado à presença de linfonodos comprometidos. Nossos dados sugerem que a positividade de Smad6 possa ser marcador de bom prognóstico em HNSCC
Title in English
Smads and AP-1 messenger RNA expression pattern in Head and Neck Squamous Cell Carcinoma
Keywords in English
BLOTTING NORTHERN/methods
CARCINOMA SQUAMOUS CELL/physiopathology
HEAD AND NECK NEOPLASM/physiopathology
NUCLEASE PROTECTION ASSAYS/methods
RNA MESSENGER
TRANSCRIPTION FACTOR AP 1
TRANSCRIPTION FACTORS
TRANSFORMING GROWTH FACTOR BETA
Abstract in English
Smad and AP1 messenger RNA expression may underlie disruptions affecting TGFb signaling in head and neck squamous cell carcinoma (HNSCC). Analysis of Smads1-8 mRNA expression by RPA has shown Smad expression is globally increased in tumor as compared to adjacent normal tissue. Kaplan Meier survival curves and multivariate analysis revealed that Smad6 positivity in tumor was an independent good prognostic factor in HNSCC. In relation to AP-1, as measured by Northern blot, only Fra-1 was overexpressed in tumor and directly related to the presence of lymph node involvement. Our data suggest that Smad6 may be a marker of good prognosis in HNSCC
 
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Publishing Date
2005-08-11
 
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