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Master's Dissertation
DOI
10.11606/D.5.2009.tde-23032010-100838
Document
Author
Full name
Aline Gouvêa de Lima
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2009
Supervisor
Committee
Snitcovsky, Igor Moyses Longo (President)
Cervantes, Onivaldo
Novaes, Paulo Eduardo Ribeiro dos Santos
Title in Portuguese
Avaliação da eficácia da aplicação preventiva do laser de baixa potência em pacientes com mucosite oral induzida por radioquimioterapia
Keywords in Portuguese
Ensaio clínico controlado aleatório
Lasers
Mucosite
Neoplasias de cabeça e pescoço
Quimioterapia
Radioterapia
Abstract in Portuguese
Estudo de fase III, prospectivo, aleatorizado e duplo-cego de prevenção de mucosite oral com laser de baixa potência. Foram incluídos pacientes portadores de câncer de cabeça e pescoço, tratados com radioquimioterapia. Grupo A laser 2,5 J/cm2 diariamente durante o tratamento e grupo B laser placebo. Inclusão de 75 pacientes (A/B 37/38). Grau III /IV mucosite: A/B 2a semana (4/5) P=1.0, 4a semana (4/12) P=0.04 e 6a semana (8/9) P=1.0. Interrupções da RT devido à mucosite A/B 0/6 P=0.02. Dor severa A/B 2a semana (5/5), 4a semana (8/8) e 6a semana (8/8) P=1.0. O tratamento com laser foi efetivo, tendo adiado o aparecimento da mucosite severa e reduzido as interrupções da radioterapia.
Title in English
Efficacy evaluation of prophylactic low-energy laser application in patients with radiochemotherapy-induced oral mucositis
Keywords in English
Drug therapy
Head and neck neoplasms
Lasers
Mucositis
Radiotherapy
Randomized controlled trial
Abstract in English
Phase III, prospective, randomized, double-blind study of oral mucositis prophylaxis by low energy laser. Patients included had a diagnosis of head and neck cancer and were managed with radiochemotherapy. Arm A laser 2.5 J/cm2 daily throughout treatment and B sham laser. Inclusion of 75 patients (A/B 37/38). Grade III /IV mucositis A/B: week 2 (4/5) P=1.0, week 4 (4/12) P=0.04 and week 6 (8/9) P=1.0. Treatment breaks due to mucositis A/B 0/6 P=0.02. Severe pain A/B week 2 (5/5), week 4 (8/8) and week 6 (8/8) P=1.0. Low laser therapy was effective, delaying severe mucositis and reducing radiotherapy breaks.
 
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ALINEGOUVEADELIMA.pdf (2.56 Mbytes)
Publishing Date
2010-03-25
 
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