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Master's Dissertation
DOI
10.11606/D.5.2007.tde-01062007-130618
Document
Author
Full name
Eliana Vieira Moderno
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Carvalho, Celso Ricardo Fernandes de (President)
Carvalho, Carlos Roberto Ribeiro de
Cendon Filha, Sonia Perez
Title in Portuguese
Efeito da ventilação assistida proporcional na capacidade ao exercício em pacientes com fibrose pulmonar idiopática
Keywords in Portuguese
Dispnéia
Doenças pulmonares intersticiais
Exercício
Fibrose pulmonar
Pletismografia.
Respiração artificial
Respiração com pressão positiva
Teste de esforço
Tolerância ao exercício
Abstract in Portuguese
O objetivo do presente estudo foi avaliar o efeito do suporte ventilatório com ventilação assistida proporcional (PAV) na capacidade ao exercício em pacientes com fibrose pulmonar idiopática (FPI). Dez pacientes foram submetidos a um teste cardiopulmonar de esforço máximo, prova de função pulmonar completa e 3 testes submáximos (60% da carga máxima): sem suporte ventilatório, com pressão positiva contínua nas vias aéreas (CPAP) e PAV. Foram avaliadas a capacidade de exercício, as adaptações cardiovasculares e ventilatórias e a percepção subjetiva de esforço. Uma amostra de lactato sanguíneo foi também obtida no repouso e no final do exercício. Nossos resultados mostram que a capacidade de exercício submáximo com suporte ventilatório PAV aumentou o tempo de exercício quando comparado com a CPAP e sem suporte ventilatório (respectivamente, 11,10±8,88 min, 5,60±4,74 e 4,50±3,84 min). O suporte ventilatório com PAV ocasionou uma menor demanda cardiovascular com redução do duplo produto e da freqüência cardíaca. Uma melhor oxigenação e uma menor percepção de esforço também foram observadas nos pacientes quando realizaram a atividade com PAV. Nossos resultados sugerem que o suporte ventilatório com PAV pode aumentar a tolerância ao exercício e reduzir a dispnéia em pacientes com fibrose pulmonar idiopática.
Title in English
Effects of proportional assist ventilation on exercise capacity in idiopathic pulmonary fibrosis patients
Keywords in English
Artificial respiration
Dyspnea
Exercise
Exercise test
Exercise tolerance
Interstitial lung diseases
Plethysmography.
Positive pressure respiration
Pulmonary fibrosis
Abstract in English
The objective of the present study was to evaluate the effect of ventilatory support using proportional assist ventilation (PAV) on exercise capacity in patients with idiopathic pulmonary fibrosis. Ten patients were submitted to a cardiopulmonary exercise testing, lung function and 3 submaximal exercise tests (60% of maximum load): without ventilatory support, with continuous positive airway pressure (CPAP) and PAV. Exercise capacity, cardiovascular and ventilatory adaptations and subjective perception to effort in lower limb and respiratory breathing were evaluated. Lactate plasmatic levels were obtained before and after submaximal exercise. Our results show that submaximal exercise capacity duration was increased with PAV compared with CPAP and without ventilatory support. (respectively, 11.10±8.88 min, 5.60±4.74 e 4.50±3.84 min). Ventilatory support with PAV lead to a lower cardiovascular demand such as double product and heart rate decreased. An improved arterial oxygenation and lower subjective perception to effort was also observed in patients with IPF when exercise was performed with PAV. Our results suggest that ventilatory support with PAV can increase exercise tolerance and decrease dyspnea in patients with idiopathic pulmonary fibrosis.
 
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Publishing Date
2007-07-02
 
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