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Doctoral Thesis
DOI
10.11606/T.5.2008.tde-19062008-172259
Document
Author
Full name
Nadjanara Dorna Bueno
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Dulley, Frederico Luiz (President)
Chamone, Dalton de Alencar Fischer
Chiattone, Carlos Sérgio
Nicolau, José Eduardo
Yoshinari, Natalino Hajime
Title in Portuguese
O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: análise de 62 pacientes
Keywords in Portuguese
Doença enxerto-hospedeiro/mortalidade
Leucemia mielocítica aguda/mortalidade
Toxicidade de drogas/mortalidade
Transplante autólogo/estatística & dados numéricos
Transplante de células-trono hematopoéticas
Transplante homólogo/estatística & dados numéricos
Abstract in Portuguese
O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: analise de 62 pacientes. Os pacientes foram submetidos a transplante de células tronco hematopoéticas alogênico e autogênico. Ao final do estudo estavam vivos no alogênico 43,3% e no autogênico 62,5%. Consolidação intensiva teve melhor sobrevida no alogênico. Os pacientes com DECH aguda grau II tiveram melhor sobrevida. Dois pacientes com DECH crônica extensa morreram. Óbito por infecção ocorreu com maior freqüência no alogênico seguido de recidiva. No autogênico a recidiva foi a principal causa de óbito. Morte por toxicidade ocorreu em 47% dos pacientes que foram a óbito no alogênico e em 8,3% no autogênico. Na analise múltipla de Cox a consolidação intensiva e DECH crônica, tiveram significância.
Title in English
The allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission: analyses of 62 patients
Keywords in English
Drugs toxicity/mortality
Graft vs host disease/mortality
Hematopoetic stem cell transplantation
Leukemia myelocytic acute/mortality
Transplantation autologous/statistics & numerical data
Transplantation homologous/statistics & numerical data
Abstract in English
The allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission: analyses of 62 patients. The patients were submitted to allogeneic and autologous hematopoietic stem cell transplantation. The end of the study were kept alive in allogeneic 43,3% and in autologous 65,2%. Patient in allogeneic who were consolidated had better survival. Patients with acute GVHD grade II had better survival. Two patients with chronic GVHD in intense, died. Infection was the most frequent dead cause in allogeneic following relapse. In autologous the relapse was the principal cause of death. Toxicity occurred in 47% of patients who died in allogeneic and 8,3% in autologous. In cox multiple analyses intensive consolidation and chronic GVHD had significance.
 
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Publishing Date
2008-06-27
 
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