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Master's Dissertation
DOI
10.11606/D.58.2009.tde-19032010-112217
Document
Author
Full name
Giselle de Angelo Souza Leite
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2009
Supervisor
Committee
Gerlach, Raquel Fernanda (President)
Borsatto, Maria Cristina
Sousa, Frederico Barbosa de
Title in Portuguese
Efeitos do chumbo na formação do esmalte fluorótico em ratos
Keywords in Portuguese
chumbo
flúor
fluorose
incisivos de ratos
poluição ambiental
Abstract in Portuguese
A co-exposição ao chumbo e ao flúor pode alterar o grau de fluorose dental, uma vez que ambos se depositam nos tecidos dentais. Ratos Wistar foram separados em 4 grupos: controle e 3 grupos que recebiam água contendo 100ppm de flúor (F), 30ppm de chumbo (Pb), ou 100ppm de F mais 30ppm de Pb desde a gestação. Análise do esmalte e determinação das dosagens de F no esmalte, dentina e osso foram realizadas nos animais com 81 dias. Defeitos nos incisivos dos ratos foram usados como escores em um índice que discriminou lesões na superfície como bandas, ilhas e cavidades. Não houve diferenças nas concentrações de F nos tecidos calcificados entre os grupos F e F+Pb. Os grupos controle e chumbo apresentaram esmalte normal. O grupo F+Pb apresentou defeitos de esmalte mais severos quando comparados com o grupo F (P<0.001). Este estudo mostrou que o Pb exacerbou a fluorose dental em roedores, sugerindo que a co-exposição ao PB pode explicar as diferenças na prevalência de fluorose.
Title in English
Effects of lead in the formation of fluorotic enamel in rats
Keywords in English
environmental pollution
fluoride
fluorosis
lead
rat incisor
Abstract in English
Co-exposure to lead and fluoride may alter the degree of dental fluorosis, since both accumulate in calcified tissues. Wistar rats were allocated in four groups: control, and 3 groups that received water containing 100 ppm of fluoride (F), 30 ppm of lead (Pb), or 100 ppm of F and 30 ppm of Pb (F+Pb) since gestational age. Enamel analysis and F determinations in enamel, dentine, and bone were performed in 81-day-old animals. Incisor defects were scored using an index that discriminated surface lesions as bands, islets, and pits. There were no differences in the F concentration in calcified tissues between the F and F+Pb groups. The control and the Pb groups presented normal enamel. The F+Pb group presented more severe enamel defects compared with the F group (P<0.001). This study shows that Pb exacerbates dental fluorosis in rodents, suggesting that co-exposure to Pb may explain differences in fluorosis prevalence.
 
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me_gisele_leite.pdf (1.19 Mbytes)
Publishing Date
2010-10-08
 
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