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Master's Dissertation
DOI
10.11606/D.59.2011.tde-08072011-130149
Document
Author
Full name
Rafael Arantes
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2011
Supervisor
Committee
Silva Filho, Antonio Carlos Roque da (President)
Pinto, Reynaldo Daniel
Tinós, Renato
Title in Portuguese
Programa de computador para simulação de modelos de neurônios: aplicação à célula mitral do bulbo olfatório
Keywords in Portuguese
bulbo olfativo
canal iônico
célula mitral
equação diferencial
modelo biofísico
Neurônio
Abstract in Portuguese
O presente trabalho descreve um programa de computador em linguagem Java que reproduz o modelo compartimental reduzido de célula mitral do bulbo olfativo construído por Davison, Feng e Brown (Brain Res. Bull. 51:393-399,2000), como uma simplificação do modelo detalhado de Bhalla e Bower (J. Neurophysiol., 69:1948-1965, 1993). O modelo reduzido considera a célula mitral como composta por quatro compartimentos, modelados conforme a metodologia de HODGKIN e HUXLEY. Por seu baixo custo computacional, o modelo reduzido permite a construção de modelos de rede de grande porte para o bulbo olfativo. A implementação computacional feita em Java apresenta grande similaridade com a original, indicando uma robustez do modelo com relação a versões em plataformas distintas.
Title in English
Computer program for neuron models simulation: application to the olfactory bulb mitral cell
Keywords in English
biophysical model
differentials equations
ionic channel
mitral cell
Neuron
olfactory bulb
Abstract in English
This work describes a computer program written in Java, which reproduces the reduced compartimental model of the mitral cell of the olfactory bulb constructed by Davison, Feng and Brown (Brain Res. Bull. 51:393-399,2000), as a simplified version of the detailed model of Bhalla and Bower (J. Neurophysiol., 69:1948-1965, 1993). The reduced model considers the mitral cell as composed of four compartiments modeled according to the Hodgkin-Huxley formalism. Due to its low computational cost, the reduced model allows the construction of large-scale network models of the olfactory bulb. The computer implementation made in Java shows great similarity with the original, indicating that the model is robust with respect to implementations in different platforms.
 
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Dissertacao.pdf (937.92 Kbytes)
Publishing Date
2011-09-19
 
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